Abstract: Objective：To compare the effect of captopril sublingual combined with nitroglycerin intravenous drip in the treatment of hypertension emergency. Methods：103 patients with hypertension emergency in our hospital from March 2016 to March 2017 were selected， and the patients were divided into two groups， the observation group (n=55) and the control group (n=48). The control group was given nitroglycerin intravenous drip， while the observation group was given captopril sublingual plus nitroglycerin intravenous drip. The clinical effect of patients after treatment was compared. The changes of diastolic pressure， systolic pressure and heart rate were recorded before and after treatment. The incidence of adverse reactions such as dizziness and tinnitus， tachycardia and heart rate accelerated after treatment were recorded. The satisfaction rate of the two groups after treatment was compared， and the change social function of psychological function， material life， total score and other quality of life changes. Results：After treatment， the total effective rate of the observation group （94.55%） was higher than that of the control group (75.00%). The difference was statistically significant (P<0.05). After treatment， the indexes of systolic pressure and systolic pressure in the two groups were lower than those before treatment， the difference was statistically significant (P<0.05)， and the above of indicators the observation group were lower than the control group， the difference was statistically significant (P<0.05). After treatment， the heart rate indexes of the two groups were lower than that before treatment， the difference was statistically significant(P<0.05)， and the observation group was lower than the control group， the difference was statistically significant(P<0.05). During the treatment， patients in the two groups had adverse reactions such as dizziness tinnitus， tachycardia and heart rate quickening. The incidence of adverse reactions of observation group was 7.27%， lower than that of the control group (25.00%). The difference between the two groups had been statistically significant(P<0.05). After treatment， the satisfaction rate of the observation group was 92.73%， the satisfaction rate of the patients in the control group was 72.92%， and the observation group was higher. After treatment， the scores of the social function， material life， mental function and total score of the two groups were higher than those before treatment， and the difference was statistically significant(P<0.05)， and after treatment， the quality of life in the observation group was higher than that in the control group， and the difference between the two groups was statistically significant (P<0.05). Conclusion： The use of captopril sublingual and nitroglycerin intravenous drip to treat hypertension emergency can quickly reduce the blood pressure level to the normal level，improve the patient′s heart rate， improve the patient′s quality of life，reduce the incidence of adverse reactions，improve the satisfaction rate of the patients.