Abstract: Objective：To analyze the use of antipsychotic drugs in psychiatric region in our hospital. Methods：The types of antipsychotic drugs， the frequency of drug use (DDDs)， the sales amount， daily cost (DDC) and the ranking ratio (B/A) were analyzed retrospectively in the psychiatric region of our hospital from 2015 to 2017，to explore the rationality of antipsychotic drugs use. Results：①The sales amount of antipsychotic drugs showed annual growth increasing trend in the psychiatric region in our hospital from 2015 to 2017， among which， the sales amount of atypical antipsychotic drugs increased rapidly every year， while the typical antipsychotic drugs showed a decreasing trend. ②Clozapine tablets， aripiprazole orally disintegrating tablets， risperidone had the largest DDDs of antipsychotic drugs in 2015， the DDDs of the other antipsychotic drugs increased rapidly except clozapine tablets and ziprasidone hydrochloride in 2016 and 2017. ③During 2015 to 2017， The DDC of other antipsychotic drugs did not change significantly except of clozapine tablets, sulpiride tablets, chlorpromazine tablets, haloperidol injection haloperidol tablets and risperidone. ④The B/A of most atypical antipsychotic drugs was more than 1 or nearly 1 except olanzapine and amisulpride， while the B/A of typical antipsychotic drugs was more than 1 except of haloperidol injection and haloperidol decanoate injection. Conclusion：The use of antipsychotic drugs in our hospital is reasonable， and the dosing of atypical antipsychotic drugs with good efficacy and high safety shows an increasing tendency year by year. But the clinician still should choose medicines reasonably according to the patient′s state of illness to and economic condition， to use drugs effectively and safely.