组织型纤溶酶原激活物-抑制剂复合物(t-PAIC)      在冠心病患者中表达变化及与预后相关性分析

摘要/Abstract

摘要： 目的：探讨组织型纤溶酶原激活物-抑制剂复合物(t-PAIC)在冠心病患者中表达变化及与预后相关性分析。方法：选择2016年4月至2017年12月我院检验科收治的173例冠心病患者及非冠心病患者50例进行本次研究。根据临床症状、心电图表现、心肌酶指标、冠状动脉造影等结果，将冠心病患者分为不稳定性心绞痛组（n=103）、稳定性心绞痛组（n=70）。再根据冠状动脉造影结果，分为单支血管病变组（n=38）、双支血管病变组（n=64）及三支血管病变组（n=71）。探讨t-PAIC在冠心病患者中表达变化及与预后相关性分析。结果：不稳定性心绞痛组患者的肌酸激酶同工酶（CKMB）、总胆固醇（TC）、C反应蛋白（CRP）、空腹血糖（FBG）均高于稳定性心绞痛组和非冠心病组（P<0.05）；稳定性心绞痛组的CKMB、CRP均高于非冠心病组（P<0.05）。不稳定性心绞痛组的血浆组织型纤溶酶原激活物抑制剂1（PAI-1）浓度高于稳定性心绞痛组和非冠心病组，而前者的血浆组织型纤溶酶原激活物（t-PA）浓度低于后两者，差异均有统计学意义（P<0.05）；稳定性心绞痛组的血浆PAI-1浓度高于非冠心病组，血浆t-PA浓度低于后者，差异均有统计学意义（P<0.05）。非冠心病组、单支血管病变组、双支血管病变组、三支血管病变组的血浆PAI-1浓度依次升高，而血浆t-PA浓度依次降低，且组间比较，差异均具有统计学意义（P<0.05）。结论：t-PAIC浓度与冠脉狭窄数、疾病严重程度呈相关性，可作为临床上预测冠心病患者预后的血清学指标。

Abstract: Objective： To analyze expression of tissue plasminogen activator inhibitor complex（t-PAIC） in patients with coronary heart disease and its correlation with prognosis. Methods： From April 2016 to December 2017， 173 patients with coronary heart disease and 50 patients without coronary heart disease were selected for this study. Firstly， according to clinical symptoms， electrocardiogram， myocardial enzyme index and coronary angiography， patients with coronary heart disease were divided into unstable angina pectoris group (n=103)， stable angina pectoris group (n=70). Secondly， according to the results of coronary angiography， they were divided into single vessel disease group (n=38)， double vessel disease group (n=64) and three vessel disease group (n=71). To analyze expression of t-PAIC in patients with coronary heart disease and its correlation with prognosis. Results： The levels of CKMB， TC， CRP， FBG in unstable angina pectorts group were higher than those in stable angina pectoris group and non-coronary heart disease group (P<0.05). The levels of CKMB， CRP in stable angina pectoris group were higher than those in non-coronary heart disease group (P<0.05). The plasma concentration of plasminogen activator inhibitor 1（PAI-1） of unstable angina pectoris group was higher than that of stable angina pectoris group and non-coronary heart disease group， while the plasma concentration of tissue plasminogen activator（t-PA） of unstable angina pectoris group was lower than that of stable angina pectoris group and non-coronary heart disease group (P<0.05). The plasma concentration of PAI-1 of stable angina pectoris group was higher than that of non-coronary heart disease group， and the plasma concentration of t-PA was lower than that of non-coronary heart disease group (P<0.05). The plasma concentration of PAI-1 in non-coronary heart disease group， single vessel disease group， double vessel disease group and three vessel disease group increased in turn， while the plasma concentration of t-PA decreased accordingly， and the difference between groups was statistically significant (P<0.05). Conclusion： Plasma t-PAIC concentration is positively correlated with the number of coronary stenosis and the severity of the disease. It can be used as a serological index to predict the prognosis of patients with coronary heart disease.

刘雅静,耿汉科. 组织型纤溶酶原激活物-抑制剂复合物(t-PAIC) 在冠心病患者中表达变化及与预后相关性分析[J]. .

LIU Yajing and GENG Hanke. Expression of Tissue Plasminogen Activator Inhibitor Complex in Patients with Coronary Heart Disease and Its Correlation with Prognosis[J]. .

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组织型纤溶酶原激活物-抑制剂复合物(t-PAIC) 在冠心病患者中表达变化及与预后相关性分析

Expression of Tissue Plasminogen Activator Inhibitor Complex in Patients with Coronary Heart Disease and Its Correlation with Prognosis

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