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纠正亚低温联合限制性液体复苏对严重腹部创伤-失血性休克患者预后的影响

贾炳学   

  1. 北京市平谷区医院 急诊外科 101200
  • 收稿日期:2019-01-28 修回日期:2019-03-11 出版日期:2019-03-25

Effects of Correcting Hypothermia Combined with Limited Fluid Resuscitation on Patients with Severe Abdominal Trauma-Hemorrhagic Shock

JIA Bingxue   

  1. Pinggu District Hospital, Beijing
  • Received:2019-01-28 Revised:2019-03-11 Online:2019-03-25

摘要: 目的:探讨纠正亚低温联合限制性液体复苏对严重腹部创伤-失血性休克(trauma-hemorrhagic shock,THS)患者预后的影响。方法:选取2016年1月至2018年12月我院收治的严重腹部THS患者110例,采用随机数字表法分成观察组与对照组,每组各55例。对照组给予限制性液体复苏治疗,观察组采用纠正亚低温联合限制性液体复苏治疗。对比两组患者治疗前后血流动力学指标[混合静脉血氧饱和度(SvO2)、心脏指数(CI)、中心静脉压(CVP)]、凝血酶原时间(PT)、活化部分凝血活酶时间(APTT)、动脉血乳酸(ABL)、炎性因子[C反应蛋白(CRP)、白介素-6(IL-6)、白介素-10(IL-10)]水平变化,病死率及并发症发生情况。结果:两组治疗2 h后SvO2、CI、CVP、APTT及血清IL-10水平较治疗前均升高(P<0.05),ABL值及血清CRP、IL-6浓度均降低(P<0.05),且观察组改善更显著(P<0.05)。与治疗前对比,观察组治疗后PT值下降(P<0.05),而对照组PT值上升(P<0.05)。观察组的病死率、并发症发生率分别为(3/55)5.45%、(4/52)7.69%,低于对照组的(10/55)18.18%、(11/45)24.44%(P<0.05)。结论: 严重腹部THS患者应用纠正亚低温联合限制性液体复苏治疗能有效改善患者血流动力学状态,纠正凝血功能障碍,减轻炎性损伤,降低病死率,减少并发症。

Abstract: Objective: To investigate the effect of correcting hypothermia combined with limited fluid resuscitation on the prognosis of patients with severe abdominal trauma-hemorrhagic shock (THS). Methods: A total of 110 patients with severe abdominal THS admitted to our hospital from January 2016 to December 2018 were enrolled. According to the random number table method, the patients were randomly divided into the observation group and the control group, 55 cases in each group. The control group was treated with limited fluid resuscitation, and the observation group was treated with correcting hypothermia combined with limited fluid resuscitation. Changes of hemodynamic parameters [mixed venous oxygen saturation (SvO2), cardiac index (CI), central venous pressure (CVP)], prothrombin time (PT), activated partial thromboplastin time (APTT), arterial blood lactate (ABL), inflammatory factors [C-reactive protein (CRP), interleukin-6(IL-6), interleukin-10(IL-10)] levels before and after treatment, case fatality rate and occurrence of complications were compared between the two groups. Results: 2 h after treatment,the levels of SvO2, CI, CVP, APTT and serum IL-10 in the two groups were higher than those before treatment (P<0.05), and the ABL and serum CRP and IL-6 levels were lower (P<0.05). The improvement of the observation group was more significant (P<0.05). Compared with before treatment, the PT value of the observation group decreased significantly after treatment (P<0.05), while the PT value of the control group increased (P<0.05). The case fatality rate and incidence of complications of the observation group were (3/55)5.45% and(4/52)7.69% respectively, which were lower than (10/55)18.18% and(11/45)24.44% of the control group (P<0.05). Conclusion: In treating patients with severe abdominal THS, the combination of correcting hypothermia and limited fluid resuscitation can effectively improve the hemodynamic conditions in patients, correct their coagulation disorders, mitigate inflammatory injury as well as reduce case fatality rate and occurrence of complications.