类固醇糖尿病相关致病因素的研究进展

类固醇糖尿病相关致病因素的研究进展

王嘉祺,梁伟时,李硕峰,门秀丽

华北理工大学,华北理工大学,华北理工大学,华北理工大学

收稿日期:2019-04-15 修回日期:2019-04-15 出版日期:2019-04-25
基金资助:
国家自然科学基金项目（项目编号：81370918；项目名称：GSK-3β在糖皮质激素诱导胰岛β细胞功能衰退中的作用及分子机制研究）

Research Progress of Related Pathogenic Factors for Steroid-induced Diabetes Mellitus

WANG JiaQi,LIANG WeiShi,LI ShuoFeng and MEN XiuLi

North China University of Science and Technology,North China University of Science and Technology,North China University of Science and Technology,North China University of Science and Technology

Received:2019-04-15 Revised:2019-04-15 Online:2019-04-25

摘要/Abstract

摘要： 类固醇糖尿病（steroid-induced diabetes mellitus，SDM）是一种继发性糖尿病，其发病主要与肾上腺皮质的糖皮质激素异常分泌或应用过量的外源性糖皮质激素有关，类似于2型糖尿病，SDM的主要致病机制包括胰岛β细胞功能障碍和胰岛素抵抗（insulin resistance， IR）。SDM具有明显的流行病学特征，发病率因致病因素的差异而不同，其引起的血糖水平升高有可逆性。了解其发病机制和相应的致病因素，对预防SDM的发生和对症高效治疗SDM均有十分重要的意义。

Abstract: Steroid-induce diabetes mellitus (SDM) is a type of secondary diabetes mellitus，which is mainly associated with abnormal secretion of glucocorticoids from the adrenal cortex or excessive application of exogenous glucocorticoids.Similar to type 2 diabetes， the main pathogenesis of SDM includes dysfunction of pancreatic β cells and insulin resistance (IR). SDM has obvious epidemiological characteristics，the incidence of SDM varies with the pathogenic factors，and the blood glucose of high level increase caused by SDM is reversible.Understanding its pathogenesis and corresponding pathogenic factors is of great significance for preventing the occurrence of SDM and effectively treating SDM.

王嘉祺,梁伟时,李硕峰,门秀丽. 类固醇糖尿病相关致病因素的研究进展[J]. .

WANG JiaQi,LIANG WeiShi,LI ShuoFeng and MEN XiuLi. Research Progress of Related Pathogenic Factors for Steroid-induced Diabetes Mellitus[J]. .

参考文献

[1] Li H, Zhang L, Xu M. Dexamethasone prevents vascular damage in earlystage non-freezing cold injury of the sciatic nerve[J]. Neural Regeneration Research, 2016, 11:163-167.
[2] Abdelmalak BB,SYou J,SKurz A, et al. The effects of dexamethasone, light anesthesia, and tight glucose control on postoperative fatigue and quality of life after major noncardiac surgery: A randomized trial[J]. J Clin Anesth, 2019, 55:83-91.
[3] Bhandage SG, Kurki MS, Sachdeva G, et al. Evaluation of efficacy of peri-operative administration of hydrocortisone and dexamethasone in prevention of post-operative complications in oral and maxillofacial surgeries[J]. Revista Española de Cirugía Oral y Maxilofacial, 2018, 40: 163-168.
[4]欧阳子倩,余争平,董兆君,等.硫化氢吸入中毒救治实验研究及救治方案建议[J].解放军预防医学杂志,1992,10:19-24.
[5] Hoogwerf B, Danese RD. Drug selection and the management of corticosteroid-related diabetes mellitus[J]. Rheum Dis Clin North Am, 1999, 25:489-505.
[6]刘丽,宋囡,李军,等.毛蕊异黄酮葡萄糖苷与葛根素及其配伍对胰岛素抵抗脂肪细胞氧化应激的影响[J].辽宁中医杂志,2019,46:116-119.
[7] Mazziotti G, Gazzaruso C, Giustina A. Diabetes in Cushing syndrome: basic and clinical aspects[J].Trends Endocrinol Metab, 2011, 22:499-506.
[8] Costa MM, Violato NM, Sebastiao RT, et al. Reduction of insulin signaling pathway IRS-1/ IRS-2/AKT/mTOR and decrease of epithelial cell proliferation in the prostate of glucocorticoid-treated rats[J]. Int J Exp Pathol, 2012, 93:188-195.
[9] Brennan-Speranza TC, Henneicke H, Gasparini SJ, et al. Osteoblasts mediate the adverse effects of glucocorticoids on fuel metabolism [J]. J Clin Invest, 2012, 122:4172-4189.
[10] Penfomis A, Kury-Paulin S. Immunosuppressive drug-induced diabetes[J]. Diabetes Metab, 2006, 32:539-546．
[11]殷峻,陈名道,周丽斌,等.长程高脂饮食对实验大鼠糖尿病形成的影响[J].中国医师杂志, 2004, 6:47-49.
[12]张鑫愉,周晓勐,牛燕媚,等.mTOR复合物在有氧运动改善小鼠骨骼肌糖代谢过程中的作用[J].中国运动医学杂志, 2018, 37:1017-1023.
[13]谢彬,劳干诚,徐刚,等.高脂饮食对大鼠胰岛细胞凋亡的影响[J].中国社区医师(医学专业), 2010, 12:15+17.
[14]周贺. GSK-3β在类固醇糖尿病小鼠胰岛β细胞凋亡中的作用[D].华北理工大学, 2016.
[15]李涛,刘刚,陈龙,等.饮食干预对妊娠期糖尿病小鼠子代中远期瘦素及糖脂代谢的影响[J].现代预防医学, 2016, 43:2794-2797+2810.
[16] Sharif K, Watad A, Coplan L, et al. Psychological stress and type 1 diabetes mellitus: what is the link?[J]. Expert Rev Clin Immunol, 2018,14:1081-1088.
[17] 赵莉,覃媛,蔡轶,等.新生期母子分离对大鼠2型糖尿病进程的影响[J].暨南大学学报(自然科学与医学版), 2017, 38:69-74.
[18] Juster RP, Sasseville M., Giguère CÉ, et al. Elevated allostatic load in individuals presenting at psychiatric emergency services[J]. J Psychosom Res, 2018, 115:101-109.<sub><sup> .</sup></sub>
[19] Henson JB, Sise ME. The association of hepatitis C infection with the onset of CKD and progression into ESRD[J]. Semin Dial, 2019, 32:108-118.
[20]SCM Bulka, VW Persky, ML Daviglus, et al. Multiple metal exposures and metabolic syndrome: A cross-sectional analysis of the National Health and Nutrition Examination Survey 2011-2014[J]. Environ Res, 2019, 168:397-405.
[21] JM Goldstein, T Hale, SL Foster, et al. Sex differences in major depression and comorbidity of cardiometabolic disorders: impact of prenatal stress and immune exposures[J]. Neuropsychopharmacology, 2019, 44:59-70.
[22] Ng TP, Lu Y, Choo RWM, et al. Dysregulated homeostatic pathways in sarcopenia among frail older adults[J]. Aging Cell, 2018,17(6): e12842.
[23] ZE Karaali, G Candan, MB Aktu?lu, et al. Toll-Like Receptor 2 (TLR-2) Gene Polymorphisms in Type 2 Diabetes Mellitus[J]. Cell J, 2019, 20:559-563.
[24] Jeong JH, Koo JH, Cho JY, et al. Neuroprotective effect of treadmill exercise against blunted brain insulin signaling, NADPH oxidase and Tau hyperphosphorylation in rats fed a high-fat diet[J]. Brain Res Bull, 2018, 142:374-383.
[25] Chakraborty D, Bernard JJ. Lipectomizing Mice for Applications in Metabolism[J]. Methods Mol Biol, 2019, 1862:245-250.
[26] Sharma A , Maurya CK , Arha D ,et al. Nod1-mediated lipolysis promotes diacylglycerol accumulation and successive inflammation via PKCδ-IRAK axis in adipocytes[J]. Biochim Biophys Acta Mol Basis Dis, 2019, 1865:136-146.
[27] Yang LW , Song M , Li YL , et al. L-Carnitine inhibits the senescence-associated secretory phenotype of aging adipose tissue by JNK/p53 pathway[J]. Biogerontology, 2019, 20:203-211.S
[28] Mennerich D, Kellokumpu S, Kietzmann T. Hypoxia and Reactive Oxygen Species as Modulators of Endoplasmic Reticulum and Golgi Homeostasis[J]. Antioxid Redox Signal, 2019, 30 :113-137.
[29] 雷义,金文达,陈锋.活性氧与线粒体损伤[J].南华大学学报(医学版), 2006, 34:648-649+657.
[30] 李泽君,呼丹,熊克朝,等.活性氧与线粒体损伤研究概述[J].中南药学, 2014, 12:989-993.
[31] 黄敏.暴露亚中毒阈剂量毒死蜱对新生鼠中脑黑质多巴胺能神经元线粒体的影响[D]. 中南大学, 2011.

快速检索引用检索图表检索高级检索