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贯叶金丝桃提取物药物相互作用的研究进展

刘华强,王红程,苗莹   

  1. 青岛市市立医院,青岛市市立医院,青岛市市立医院
  • 收稿日期:2018-12-13 修回日期:2019-04-03 出版日期:2019-04-25

Research Progress on Drug Interactions of Hypericum perforatum L. Extract

Liu HuaQiang,Wang HongCheng and Miao Ying   

  1. qingdaoshishiliyiyuan,qingdaoshishiliyiyuan,qingdaoshishiliyiyuan
  • Received:2018-12-13 Revised:2019-04-03 Online:2019-04-25

摘要: 目的:探讨贯叶金丝桃提取物对其他药物药动学及药效学的影响,为临床安全用药提供参考。方法:对文献资料进行分析,就贯叶金丝桃对治疗药物的药动学和药效学影响进行综述。结果与结论:贯叶金丝桃能够引起多种药物(环孢素A、他克莫司、地高辛、阿米替林、伊马替尼、伊立替康、华法令、口服避孕药等)体内动力学和药效学的改变,临床在合并使用时应引起足够的重视。

Abstract: Objective: To investigate the pharmacokinetics and pharmacodynamics effects of Hypericum perforatum L. on other drugs,and to provide references for clinical safe medication. Methods: Through analysis of documentation, the pharmacokinetic and pharmacodynamic effects of Hypericum perforatum L. on therapeutic drugs were reviewed. Results & Conclusion: Hypericum perforatum L. can induce changes in pharmacokinetics and pharmacodynamics of various drugs (cyclosporine A, tacrolimus, digoxin, amitriptyline, imatinib, irinotecan, warfarin,oral contraceptives, etc.),which should be paid enough attention in clinical use..