Abstract: Objective： To investigate the application of total parenteral nutrition(TPN) in perioperative period of patient with digestive malignant tumor in a hospital， providing reference for the rational drug use. Methods： Retrospectively， the application of TPN in 96 malignant tumor surgery inpatients during January 2018 to July 2018 in a hospital were analyzed statistically.Results： The 96 malignant tumor surgical inpatients were mainly the elderly， proportion of gastric cancer reached 57.3%. Patients totally received TPN 918 times， and the average use period was (9.6±4.2)d. The average energy of TPN prescriptions was (21.1±4.4)kcal·kg-1·d-1， and the energy of 39.5% prescriptions were less than 20 kcal·kg-1·d-1. The average glycolipids energy supply ratio was 1±0.4， and the proportion of prescriptions with glycolipids energy supply ratio below 1 was 41.6%.The average amino acids of TPN prescriptions was (1.3±0.4)g·kg-1·d-1， and the proportion of prescriptions with hot nitrogen ratio of 80-150：1 was 84.4%. There were 81.3% prescriptions used alany glutamine， and the alanyl glutamine accounted for more than 20% of the amino acid in the 41.7% prescriptions. The osmotic pressure， amino acid concentration， glucose concentration， and monovalent and bivalent cations qualified rates of parenteral nutrition were 95.8%， 92.7%， 96.8%， 94.8% and 95.9% respectively. Conclusion： The nutritional support in the perioperative period of malignant tumor surgery in the hospital is mainly after operation， lack of preoperative individualized nutritional risk assessment and nutritional support. The perioperative TPN prescription is basically reasonable， however， some prescriptions are deficient in heat/protein supply， excessive in fat emulsion supply， unsuitable in heat and nitrogen ratio and exceeded the standard in electrolyte and drug concentration. Clinical nutrition support is a multidisciplinary work. Clinical pharmacists should actively assist physicians and develop individualized nutritional support programs to improve the safety and effectiveness of clinical nutrition treatment.