Abstract: With the transformation of the medical model from the "biomedical model" to the "biological-psychological-social medical model" and the breakthrough of the basic theoretical research of TCM， the TCM constitutional science is in the establishment and improvement of the theoretical system， and in clinical applications and practice has been fully developed. The research and development of TCM constitutiona can help to understand the susceptibility of different populations and diseases， and to the prevention and treatment of diseases for different types of people. The idea of "prevention and treatment" is the concrete manifestation of the theory of "treatment without disease". Practice in the field of “not sick” provides a basis for individualized diagnosis and treatment and disease prevention.