Abstract: Objective：To explore a more suitable health management model for perimenopausal syndrome through the implementation of two different modes of health management for menopausal women. Methods： According to the different locations of the first visit， the patients were divided into the intervention group and the control group. The intervention group adopted the two level whole process management mode， while the control group adopted the traditional specialist hospital visiting management mode. The modified Kupperman scores of the two groups of subjects were compared before and after improvement. Drug compliance was compared between the two groups. Results： After health education， the awareness rate of related knowledge in the control group was higher than that in the intervention group， and the difference was statistically significant (P<0.05). The symptoms of the two groups were significantly improved， and there was no significant difference in the modified Kupperman score (P>0.05). The compliance of the intervention group was higher than that of the control group， and the difference was statistically significant (P<0.05). Conclusion： The whole process management mode can make early intervention， standardize treatment and improve follow-up， which is effective not only in improving symptoms， but also in improving patients′ compliance.