Abstract: Objective：To investigate the clinical significance of the application of drospirenone ethinylestradiol tablets after missed abortion curettage. Methods：A total of 60 patients who underwent uterine evacuation surgery for missed abortion in our hospital from May to October 2017 were enrolled. The observation group (30 cases) received general treatments after uterine curettage (oral cefixime and intramuscular injection of oxytocin for 3 d)，and on that basis added drospirenone ethinylestradiol tablets (oral administration for 3 cycles). The control group (30 cases) received general treatment after uterine curettage. The indicators after uterine curettage were compared， such as the duration of vaginal bleeding， the total amount of vaginal bleeding after surgery， and the length of menstrual recovery. The gynecologic ultrasonography inspection was taken 2 weeks after the operation to observe the recovery of the endometrium. The occurrence of increased vaginal secretion， lower abdominal pain， and decreased menstrual flow after surgery were compared between the two groups. Results： Compared with the control group， the patients in the observation group had shorter time of vaginal bleeding， less vaginal bleeding， shorter menstrual recovery time and better endometrial recovery than those in the control group. The above indicators showed that the differences were statistically significant (P<0.05). The occurrence of increased vaginal secretion and lower abdominal pain symptoms after uterine curettage in the observation group was less than that in the control group. The occurrence of menstrual reductions after surgery in the observation group was less than that in the control group. Comparison of the above indicators showed statistically significant differences (P<0.05). Conclusion：The use of drospirenone ethinylestradiol tablets after missed abortion curettage can significantly reduce the time of vaginal bleeding after surgery， reduce the total amount of vaginal bleeding， shorten the time of menstrual recovery， and facilitate the recovery of endometrium after surgery，effectively reduce the incidence of pelvic infections with the symptoms of increased vaginal secretion and lower abdominal pain after surgery.