Abstract: Objective： To investigate the relationship between the severity of acute hypertriglyceridemic pancreatitis (AHTGP) and levels of C-reactive protein (CRP) and serum calcium. Methods： The clinical data of 104 patients with AHTGP in our hospital were enrolled retrospectively. The levels of CRP and serum calcium of different severity of AHTGP were compared. Spearmann correlation analysis was performed， and receiver operating characteristic curve (ROC) was used to evaluate the diagnostic efficacy of each indicator. Results： 104 patients with AHTGP were enrolled and divided into three groups for comparative analysis： 61 patients with mild acute pancreatitis (MAP)， 29 patients with moderately severe acute pancreatitis (MSAP)， and 14 patients with severe acute pancreatitis (SAP). The median findings for the MAP， MSAP， and SAP groups were as follows： CRP after admission， 8.0，46.8 and 149.5 mg·L-1 respectively (P<0.001)， serum calcium after admission， 2.20， 2.11 and 2.04 mmol·L-1， respectively (P=0.038). Spearman’s correlation analysis showed significantly positive correlation between CRP after admission level and most acute pancreatitis scoring systems， and significantly negative correlation between serum calcium after admission level and most acute pancreatitis scoring systems. Receiver operating characteristic curve （ROC）showed that the areas under the curve for CRP and serum calcium after admission were 0.854 (P<0.001) and 0.669 (P=0.043)， respectively. Conclusion：The levels of CRP and serum calcium after admission may predict the severity of AHTGP， which would play a reference role in clinical application.