Abstract: Objective： To evaluate the safety and feasibility of radical antegrade modular pancreatosplenectomy (RAMPS) for left-sided pancreatic adenocarcinoma. Methods： Clinical data of total 20 patients underwent RAMPS for left-sided pancreatic adenocarcinoma at department of hepatobiliary and pancreatic surgery in our hospital from January 2016 to December 2018 were reviewed retrospectively. Retrospective analysis of the patient′s age， sex， intraoperative conditions (operation time， surgical type， intraoperative bleeding)， tumor characteristics (tumor differentiation， tumor size， lymph node clearance， TNM staging) and other related clinicopathological data was made. The follow-up using outpatient examination or telephone review was performed to detect the patients’ survival and tumor recurrence and metastasis. Results： The operation was successfully completed in 20 patients and palliative operation was performed in 1 patient due to diffuse infiltration of tumor. The mean operative time was (356.35±135.68) min， and the mean blood loss was (250±70) mL. Only one patient required blood transfusion during surgery. Combined vascular resection was performed in 2 cases， and combined organ resection was performed in 2 cases. The mean diameter of tumor was (4.12±2.11) cm. The pathological types were all pancreatic adenocarcinoma. The mean number of retrieved lymph nodes was (21.82±10.13) and node positivity was observed in 14 patients (70%). Negative tangential margins were obtained in 16 patients. In this study， the median survival time was 22.5 months with a median follow-up period of (23.07±13.23) months. Five patients had postoperative complications. One patient had grade A fistula and two had grade B fistula； one case of hemorrhage； one case of urinary retention. No patient occurred diarrhea， intestinal obstruction and other gastrointestinal complications. Univariate analysis showed that tumor differentiation， R0 resection， pancreatic fistula and postoperative comprehensive treatment had statistically significance on long-term survival rate（P＜0.05）. Conclusion：RAMPS can provide more local treatment and radical resection opportunities for patients with locally advanced pancreatic cancer and organ invasion.