Abstract: Objective： To explore the efficacy of wenjing zhuyu decoction combined with gestrinone in patients with endometriosis (EMT)， and their impact on serum levels of vascular endothelial growth factor (VEGF)， VEGF receptor(Flk-1) and macrophage migration inhibitory factor(MMIF). Methods： 130 patients with EMT who underwent laparoscopic surgery in our hospital from January 2016 to December 2018 were divided into the observation group and the control group according to the random number method， each group had 65 cases.The control group patients were treated with gestrinone， and the observation group patients were treated with wenjing zhuyu decoction on the basis of the control group. The efficacy was observed in the two groups after treatment， and the levels of symptoms of TCM， dysmenorrhea， menstrual flow， uterine artery and its branch resistance index(RI)， pulsatility index(PI)， maximum blood flow velocity at the end of systole and maximal blood flow velocity ratio during diastole(S/D)， CA125， follicle-stimulating hormone (FSH)， estradiol (E2)， luteinizing hormone (LH)， progesterone (P)， VEGF， Flk-1 and MMIF were also observed before and after treatment. Results： The total effective rate was 92.31% in the observation group， which was better than 76.92% in the control group (P<0.01). There were no significant differences in the symptoms of TCM， dysmenorrhea， menstrual flow， CA125， FSH， E2， LH， P， RI， PI， S/D， VEGF， Flk-1 and MMIF before treatment(P>0.05)， the levels of those in two groups after treatment were significantly lower than before treatment(P<0.01)， while the reduction amplitude in the observation group was more significant compared with the control group(P<0.01). Conclusion： Wenjing zhuyu decoction combined with gestrinone has more obvious efficacy on cold coagulation type EMT， which relieves symptoms of EMT， improves uterine blood supply， and reduces female hormone levels. Its mechanism may be related to the decrease of VEGF， Flk-1 and MMIF levels.