Abstract: Objective:To study the impact of differences in treatment of early prognosis of fulminant pancreatitis, comparative evaluation of its safety.Methods:A retrospective analysis of gastroenterology admitted to hospital in Dec 2011 to Dec2014 diagnosed with fulminant pancreatitis and attributable to the early stages of the 42 patients as observed objects were randomly divided into two groups, the observation group 23 patients in the control group of 19 cases. The control group received conventional conservative treatment (non-surgical treatment), observation group received laparoscopic peritoneal lavage and drainage.All patients were treated with APACHEII score, and the changes of serum CRP and IL-6 were detected, and the mortality of the two groups were statistically analyzed.And postoperative adverse reaction rate.Results:After treatment, the clinical symptoms of the observation group were significantly lower than the control group, the difference was statistically significant (P<0.05); in addition, the mortality of the observation group was significantly lower than the control group (P<0.01), the APACHEII score, serum CRP and serum IL-6 level were also lower than the control group (P < 0.05). No obvious adverse reactions were observed in the two groups.Conclusion:Laparoscopic peritoneal lavage and drainage showed that minimally invasive surgery can relieve and eliminate the clinical symptoms of AFP patients, reduce the abnormal increase of serum CRP, IL-6 levels, and can significantly reduce the mortality, improve the survival rate of patients.