Abstract: 【ABSTRACT】Objective: To investigate the clinical characteristics and treatment of vaginal flora in late pregnancy. Methods: Select our hospital 99 cases of late pregnant patients, routine prenatal vaginal examination. Examination was positive in according to whether the symptoms were divided into group R1 (symptomatic, 33 cases) and R2 group (asymptomatic, 33 cases), into the examination was negative in R3 group (33 cases), prenatal according to the need of Lactobacillus. The dosage, length of stay, the amount of postpartum hemorrhage and the distribution of vaginal flora in 3 groups were recorded and compared with the 3 groups. Results: R1 group of Lactobacillus preparation time was significantly more than that of R2 group (P＜0.05); 3 group, the hospitalization time, produced in the amount of bleeding, postpartum hemorrhage compared no significant difference (P＞0.05); vaginal flora check Candida in 37 cases, 3 cases of Trichomonas, 5 cases of bacterial vaginosis, clothing original body gonococcus in 13 cases, 8 cases of gonococcal; R1 groups of maternal premature delivery, premature rupture of membranes, cesarean section production, puerperal infection and lower incidence of R2 group, but the difference was not significant (P＞0.05). Conclusion: Late pregnancy vaginal flora to Candida albicans, Chlamydia is common. On vaginal examination positive symptoms and give Lactobacillus treatment effective, but there was no effect on the symptoms, clinical need comprehensive consideration of the medication.