Abstract: 【Abstract】Objective:To analysis and study of atorvastatin combined benzene sulfonic acid amlodipine for treatment of coronary heart disease (CHD) with cerebral infarction. Methods: January 2013 - February 2013 selected 72 cases of coronary heart disease (CHD) with cerebral infarction patients, it is according to the odd and even number method randomly divided into observation group and control group, each group has 36 patients. Control group patients give benzene sulfonic acid amlodipine treatment; Observation group patients give atorvastatin + benzene sulfonic acid amlodipine treatment, will be 4 weeks after treatment in both groups of curative effect and adverse reaction were compared. Results: compared two groups of curative effect: the observation group of patients show efficiency is higher than the control group (P < 0.05. Two groups of patients before and after detecting blood fat index: two groups of patients before blood fat each index values were no obvious difference (P > 0.05; Observation group after treatment in patients with total cholesterol, triglyceride, low density lipoprotein cholesterol values are lower than the control group (P < 0.05. Compared two groups of patients with adverse reactions is happening: two groups of patients with no difference between the incidence of adverse drug reactions (P > 0.05). Conclusion: atorvastatin associated with benzene sulfonic acid amlodipine used in the treatment of coronary heart disease (CHD) with cerebral infarction patients, the two drugs together, each other by tiaozhi role play together delay patients development purposes, to improve the treatment effect and quality of life of patients plays an important role.