太芪培元颗粒治疗HIV感染者临床疗效观察

太芪培元颗粒治疗HIV感染者临床疗效观察

魏叶叶,马建萍

新疆医科大学,新疆医科大学附属中医医院

收稿日期:2017-11-03 修回日期:2017-11-03 出版日期:2017-12-25
基金资助:
国家“艾滋病和病毒性肝炎等重大传染病防治”科技重大专项（项目编号：2014ZX10005003；项目名称：中西医结合治疗艾滋病应用技术研究）；中医药防治重大疑难疾病临床服务能力建设项目（项目编号：201405；项目名称：太芪培元颗粒对艾滋病患者差异蛋白的研究）

Observation of Clinical Curative Effect of Taiqipeiyuan Granules to HIV-infected Patients

WEI yeye and MA Jianping

XinJiang Medical University,Traditional Chinese Medicine Hospital AffiliatedBeginEttoEndETXinjiang Medical University

Received:2017-11-03 Revised:2017-11-03 Online:2017-12-25

摘要/Abstract

摘要： 目的：观察太芪培元颗粒治疗气阴两虚肺肾不足的人类免疫缺陷病毒（HIV）感染者的临床疗效。方法：采取前瞻性队列研究的方法，纳入HIV感染者81例，给予太芪培元颗粒口服180d，按照CD4+T淋巴细胞计数上升＞50个和上升＜5个分为治疗有效组和治疗无效组，并按照性别、民族匹配选取10个样本进行病例观察。观察指标包括CD4+T淋巴细胞、CD8+T淋巴细胞、中医症状体征积分、HIV-RNA病毒载量的差异。结果：治疗有效组CD4+T淋巴细胞显著升高（P＜0.05），中医症状体征总积分显著降低（P＜0.05），治疗无效组CD4+T淋巴细胞显著降低（P＜0.05）。且总样本前后比较，中医症状体征总积分降低，差异有统计学意义（P＜0.05）；对CD4+T淋巴细胞和中医症状总积分进行Pearson相关分析得出，治疗有效组、治疗无效组以及总样本中这种相关性均无统计学意义。结论：太芪培元颗粒可有效改善气阴两虚肺肾不足型HIV感染者中医症状总积分，且这种改善与CD4+T淋巴细胞计数的升高不具有相关性。

Abstract: Objective：To observe the clinical curative effect of the HIV-infected patients who were deficiency of both qi-yin and lung-kidney by taking taiqipeiyuan granules.Methods：A prospective cohort study were conducted in 81 cases of HIV-infected patients， and oral administration of taiqipeiyuan granules were given for 180d. CD4+T lymphocyte count increased＞50 and ascending＜5 were grouped condition for the effective treatment group and ineffective treatment group，and 10 samples were selected according to gender and ethnic match for case observation. Observations included CD4+T lymphocytes，CD8+T lymphocytes，TCM symptom integrals，HIV-RNA virus load.Results：In the effective treatment group the increase of CD4+T lymphocytes and the decrease of TCM syndrome integrals were significant (P＜0.05)，and the CD4+T lymphocytes in the ineffective treatment group were significantly decreased (P＜0.05).Compared with the total sample before and after treatment， the decrease of TCM symptom integration was significant (P＜0.05).According to Pearson correlation analysis of CD4+T lymphocyte and TCM symptom integrals， this correlation was not statistically significant in the effective treatment group， the ineffective treatment group and the total sample.Conclusion：Taiqipeiyuan granules can effectively improve the integration of TCM symptoms in patients who was deficiency of both qi-yin and lung-kidney，and this improvement has no correlation with the increase of CD4+T lymphocyte count.

魏叶叶,马建萍. 太芪培元颗粒治疗HIV感染者临床疗效观察[J]. .

WEI yeye and MA Jianping. Observation of Clinical Curative Effect of Taiqipeiyuan Granules to HIV-infected Patients[J]. .

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