Abstract: Objective：To investigate the clinical efficacy between laparoscopy and laparotomy in the treatment of ectopic pregnancy and the outcome of second pregnancy.Methods：93 cases of ectopic pregnancy treated in our hospital from November 2014 to December 2016 were selected as the subjects.According to the treatment methods， there were 45 cases of open surgery (laparotomy group)， 47 cases of laparoscopy (laparoscopy group).The duration of operation， length of incision， intraoperative blood loss， exhaust time， HCG recovery time， hospitalization time， postoperative conception， pain and incidence of complications were compared between the two groups.Results：The operative time of the laparoscopy group was slightly more than that in the laparotomy group， but the difference was not statistically significant (P>0.05).The length of incision， the amount of bleeding in the operation， the time of exhaust， the time of HCG recovery and the time of hospitalization in the laparoscopy group were all lower than those in the laparotomy group， the difference was statistically significant (P<0.05).The VAS score of 6， 24，48 h after operation in the laparotomy group was higher than that in the laparoscopy group， the difference was statistically significant (P<0.05).The incidence of complications in the laparoscopy group(2.13%) was lower than the laparotomy group(13.33%)， the difference was statistically significant (P<0.05). Postoperative tubal patency comparison and intrauterine pregnancy rate comparison in laparoscopy group was higher than the laparotomy group，but the difference was not statistically significant (P>0.05). The incidence of recurrent ectopic pregnancy within 1 year in the laparoscopic group was lower than that the laparotomy group， the difference statistically significant (P<0.05)， and there was no was statistically significance in the rate of unpregnancy(P>0.05).Conclusion： Laparoscopic surgery has a good clinical effect in the treatment of ectopic pregnancy.The incision is small， postoperative pain is lower， the amount of bleeding and exhaust time is shorter， and the second pregnancy rate is higher within 1 year after operation.