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临床医药

原发性硬化性胆管炎发病机制的研究进展

  • 陈峙橦
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  • 三亚中心医院普通外科,海南 三亚 572000
陈峙橦,男,主治医师,研究方向:肝胆外科

收稿日期: 2024-10-12

  修回日期: 2025-09-02

  录用日期: 2025-12-03

  网络出版日期: 2025-12-17

基金资助

2025年三亚市人才开发专项资金项目(46020021T000000016220)

Research Progress on the Pathogenesis of Primary Sclerosing Cholangitis

  • 峙橦 陈
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  • Department of General Surgery Sanya Central Hospital Hainan Sanya 572000, China

Received date: 2024-10-12

  Revised date: 2025-09-02

  Accepted date: 2025-12-03

  Online published: 2025-12-17

摘要

原发性硬化性胆管炎(primary sclerosing cholangitis,PSC)是一种病程较缓慢、较罕见的胆道疾病,以肝内外胆管广泛纤维化为主要特点,表现为胆管壁进行性增厚、管腔狭窄,最终导致肝硬化和肝衰竭,肝移植是唯一有效的治疗方法。PSC发病原因呈现高度复杂性,发病机制尚未完全阐明。近年来,研究表明PSC的病因主要是遗传易感背景下,由异常免疫反应驱动,是以胆管上皮细胞为基础,并受肠道微生态紊乱影响的进行性疾病。多种因素(免疫、胆管、菌群、胆汁酸等)相互影响形成恶性结果,共同促进炎症、胆管破坏和纤维化进程,从而导致PSC的发生。本研究基于相关文献,从免疫学、肠道微生物菌群、感染、胆汁酸代谢、遗传等因素分别进行概述、总结,旨在为PSC的临床治疗提供新的方向及策略。

本文引用格式

陈峙橦 .

原发性硬化性胆管炎发病机制的研究进展

[J]. 中国医药导刊, 2025 , 27(10) : 1040 -1040-1045 . DOI: magtech.2024.10.12-00001

Abstract

Primary sclerosing cholangitis PSC is a relatively rare biliary disease with a slow course and characterized by extensive fibrosis of the intrahepatic and extrahepatic bile ducts resulting in progressive thickening of the bile duct wall and narrowing of the lumen ultimately leading to cirrhosis and liver failure and liver transplantation is the only effective treatment method. The causes of PSC are highly complex and the pathogenesis has not been fully elucidated. In recent years many studies have shown that PSC is a progressive disease mainly driven by abnormal immune responses under the background of genetic susceptibility based on bile duct epithelial cells and influenced by intestinal microbiota disorders. Multiple factors immunity bile ducts microbiota bile acids etc. interact to form malignant outcomes jointly promoting inflammation bile duct destruction and fibrosis processes leading to the occurrence of PSC. Based on relevant literaturethis study provides an overview and summary of the pathogenic factors PSC such as immunology gut microbiota infection bile acid metabolism genetics aiming to provide new directions and strategies for the treatment of PSC in clinical practice.

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