CHINESE JOURNAL OF MEDICINAL GUIDE ›› 2025, Vol. 27 ›› Issue (12): 1293-1293-1298.doi: 10.1009-0959.2025.120012

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Analysis of the Predictive Value of WMR for Short-Term Prognosis and the Risk Factors in Children with Acute Attack of Bronchial Asthma

LIU Shuo1，2， WANG Xiaohong3*   

  1. 1.Shanxi Medical University， Shanxi Taiyuan 030001， China；
    2.Taiyuan Maternity and Child Health Care Hospital， Shanxi Taiyuan 030001， China；
    3.First Hospital of Shanxi Medical University， Shanxi Taiyuan 030001， China
  • Received:2024-11-07 Revised:2025-10-17 Accepted:2025-12-24 Online:2025-12-28 Published:2026-01-26

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Abstract:

Objective： To explore the predictive value of white blood cell count/mean platelet volume （WMR） in short-term prognosis and the risk factors in children with acute attack of bronchial asthma （BA）.Methods： 94 children with acute attack of BA and 52 healthy children controls with matched age were enrolled as the study group and the control group between June 2022 and December 2023， respectively. The levels of white blood cell count （WBC）， mean platelet volume （MPV） and WMR were compared between the two groups. According to disease severity， children in the study group were divided into mild group， moderate group and severe group. The clinical data， laboratory indexes and WMR level of patients in the three groups were compared. According to short-term prognosis， the patients were divided into the good prognosis group and the poor prognosis group. The clinical data， laboratory indexes and WMR revels in the two groups were compared. The predictive value of WMR for short-term prognosis was analyzed by receiver operating characteristic （ROC） curves， and risk factors of short-term prognosis were analyzed by multivariate Logistic regression analysis.Results： The levels of serum WBC， MPV and WMR in the study group were higher than those in the control group （P<0.05）， and these indicators were higher in the severe group than in the moderate group and the mild group （P<0.05）. There were significant differences in allergy history， history of repeated respiratory tract infection and WMR level between the poor prognosis group and the good prognosis group （P<0.05）. ROC curves analysis showed that AUC， 95%CI， specificity and sensitivity of WMR for predicting short-term prognosis of BA children were 0.721， 0.619-0.809， 60.27% and 76.19%， respectively. Binary Logistic regression analysis showed that allergy history （OR=5.484， P=0.006）， history of repeated respiratory tract infection （OR=5.695， P=0.015） and WMR >0.93 （OR=4.053， P=0.022） were independent risk factors of short-term prognosis in children with acute attack of BA （P<0.05）.Conclusion： The level of serum WMR increases in children with acute attack of BA. It is correlated with disease severity and has certain predictive value for short-term prognosis.

  

Key words: Bronchial asthma； , Acute attack； , White blood cell count/mean platelet volume； , Short-term prognosis； , Risk factor

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