Abstract: Objective:To discuss the change and clinical significance of plasma NT-proBNP detection in the COPD patients developing process,through the plasma NT-proBNP detection for COPD patients with respiratory failure.Methods:All patients in the hospital the next day were extrated cubital vein 3mL,to prepare plasma NT-proBNP level and arterial blood gas analysis testing.Biomedical Co.,the Canadian Ruibang sharp production of dry general quantitative fluorescence analyzer in strict accordance with the instructions for plasma NT-proBNP.Blood gas analyzer were used to test RocheOmnic arterial oxygen pressure(PaO2),blood carbon dioxide partial pressure(PaCO2).Results: Serum NT-proBNP level was significantly(P<0.05),experimental group was significantly higher than the control group.Varying degrees of hypoxemia compared NT-proBNP level was significantly(P <0.05),prompts: NT-proBNPs levels increased with the decrease of PaO2.Experimental group of 68 patients with COPD PaO2and serum NT-proBNP level was negatively correlated(a 0.641,P <0.05),while PaC02 serum NT-proBNP levels with no correlation(r = 0.143,P> 0.05).Conclusion: Plasma NTproBNP level of detection of respiratory failure in COPD diagnosis,severity and prediction of development and change have better clinical value in guiding treatment of COPD patients with respiratory failure are important and warrant further study.