急性肾损伤血清半胱氨酸蛋白酶抑制剂C检测及其临床意义

急性肾损伤血清半胱氨酸蛋白酶抑制剂C检测及其临床意义

收稿日期:1900-01-01 修回日期:1900-01-01 出版日期:2012-06-25

Cystain C’s Detection and Clinical Significance inAute Kidney Injury

Received:1900-01-01 Revised:1900-01-01 Online:2012-06-25

摘要/Abstract

摘要： 目的:检测急性肾损伤患者血清半胱氨酸蛋白酶抑制剂C(Cystain C,Cys C)及其临床意义。方法:将2008年1月～2011年1月本科诊治的90例急性肾损伤患者根据AKIN共识分级标准分为AKI1期组、AKI2期组和AKI3期组,以正常健康人为对照(CON组),检测并比较血肌酐(Scr)、尿素氮(BUN)、Cys C和肾小球滤过率(GFR)的差异,分析病情严重程度与Cys C的相关性。结果:AKI1期组、AKI2期组和AKI3期组患者血清Scr、BUN和Cys C显著高于CON组(P<0.05);AKI1期组、AKI2期组和AKI3期血清Scr、BUN、GFR和Cys C的差异具有统计学意义,Scr、BUN和Cys C随着AKIN共识分级增加而增加(P<0.05),GFR随着AKIN共识分级增加而降低(P<0.05)。AKI1期组、AKI2期组和AKI3期组患者血清Cys C均与血清Scr和BUN正相关(P<0.005),与GFR负相关(P<0.005)。AKI1期组、AKI2期组和AKI3期组病情严重程度APACHEⅡ、SAPS和SOFA评分患者均与血清Cys C正相关(P<0.005)。结论:急性肾损伤患者血清Cys C随着AKIN共识分级增加而增加,病情严重程度与其成正相关关系。

Abstract: Objective:To study the Cystain C’s detection and clinical significance in Acute Kidney injury(AKI).Methods:90 cases with AKI between Jan 2008 and Jan 2011 were divided in to AKI1 group,AKI2 group和AKI3 group.Healthy people were selected for control(CON group).The serous Scr,BUN,Cystain C and GFR were compared.The correlation between AKI condition and Cystain C were analyzed.Results:The Scr,BUN and Cystain C in AKI1,AKI2 and AKI3 group were significantly higher than in CON group(P<0.05).The differences in AKI1,AKI2 and AKI3 group were significantly different(P<0.05).The Scr,BUN and Cystain C increased as AKI grading’s promotion(P<0.05).The Cystain C in AKI1,AKI2 and AKI3 group correlated positively with Scr and BUN(P<0.05),but negatively with GFR(P<0.05).APACHE Ⅱ,SAPS and SOFA cores correlated positively with Cystain C(P<0.05).Conclusion: The AKI disease’s severity correlates positively with serous Cystain C.

. 急性肾损伤血清半胱氨酸蛋白酶抑制剂C检测及其临床意义[J]. .

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