Abstract: Objective:To observe the difference of the therapeutic effects of different surgical methods in the treatment of advanced gastric cancer.Methods:A total of Sep 2011 to may 2014 in general surgery department of our hospital 168 cases of advanced gastric cancer study,were randomly divided to observation group (87 cases) and control group (81 cases),observation group received laparoscopic-assisted resection of gastric D2, the control group received laparotomy D2 resection of gastric cancer. Analysis and comparison of the two groups of patients with intraoperative and postoperative conditions and differences in immune function.Results:The laparoscopic group blood loss,incision length,postoperative drainage,ambulation time,length of hospital stay and analgesia compared with less time or short open group, and immunosuppression minor laparoscopic group (both P<0.05), but the head of the surgical time than open surgery (P>0.05);in addition,the difference between the two groups in the number of lymph node dissection and postoperative morbidity groups was not significant (all P>0.05). Conclusion:Laparoscopic gastric D2 resection than traditional open surgery has less blood loss, shorter incision,less postoperative drainage,surgical incision healing,rapid recovery of gastrointestinal function,pain relief fast, immunosuppression light, etc.