Abstract: [Abstract] Objective ：To explore the risk factors and nursing countermeasures of complication on premature infants with Peripherally Inserted Central Catheter. Method： Retrospective analysis the complications of our hospital from 2010 January to 2015 January, 180 cases of premature infants in PICC during intubation. Results：180 cases of children with complications in 39 cases, the rate was 21.67%. After corresponding nursing countermeasures after, according to the blood, heart and lung function and blood clotting condition, found in children due to complications arising PICC were cured, and the recovery of children well. Conclusion： For the PICC catheter in premature infants, the reasonable nursing intervention can significantly improve the complications caused by PICC.