Abstract: Abstract: Objective: To investigate the therapeutic effect of laparoscopic minimally invasive therapy for the treatment of gallbladder stone and cholecystitis. Methods: 72 cases of gallbladder stone complicated with cholecystitis in our hospital from February 2012 to March were selected as the research object. According to the different treatment methods, the patients were divided into experimental group and control group, 36 cases in each group. The experimental group was treated with laparoscopic minimally invasive therapy. The control group was treated with conventional open abdominal surgery. The curative effect of the two groups was observed and compared. Results: the operation time, incision length, blood loss, postoperative exhaust time and hospital stay in the experimental group were significantly better than those in the control group (P<0.05). The postoperative pain index and the incidence of complications in the experimental group were significantly lower than those in the control group (P<0.05). Conclusion: laparoscopic minimally invasive therapy in the treatment of gallbladder stones and cholecystitis has obvious curative effect, with the advantages of less trauma, faster recovery, less complications, it is worthy of clinical application.