定量CT在肺泡蛋白沉着症支气管肺泡灌洗术中应用价值分析

定量CT在肺泡蛋白沉着症支气管肺泡灌洗术中应用价值分析

王芬,贾九梅

衡水市第四人民医院,河北省衡水市第五人民医院

收稿日期:2017-10-23 修回日期:2017-10-23 出版日期:2017-12-25
基金资助:
河北省衡水市桃城区科技局项目（项目编号：20170140026Z；项目名称：CT定量肺泡灌洗术前后对肺泡蛋白沉着症的应用研究）

Application of Quantitative CT in Bronchoalveolar Lavage of Pulmonary Alveolar Proteinosis

wangfen and JIA Jiumei

The No.4 People’s Hengshui Hospital,Hengshui No.5 People′s Hospital

Received:2017-10-23 Revised:2017-10-23 Online:2017-12-25

摘要/Abstract

摘要： 目的：研究定量CT在肺泡蛋白沉着症（PAP）支气管肺泡灌洗术中的应用价值。方法：回顾性地选取2015年1月至2016年6月在本院治疗的PAP患者共12例，其中男性9例，女性3例，平均年龄（40.6±4.3）岁；共计灌洗20次，包括8例1次、3例2次、1例3次。对比灌洗前后患者的平均肺密度、肺部总重量、肺部总容积、肺部CT值及肺功能指标。结果：相比灌洗术前，PAP患者灌洗术后肺部总容积（1655.23±832.13）mL、用力肺活量（2.79±0.85）L、第一秒用力呼气量（3.03±0.38）L有所增加，但差异无统计学意义（P>0.05）；而灌洗后患者PaO2（15.2±4.21）kpa、肺一氧化碳弥散量（55.35±20.29）%、肺一氧化碳弥散量常数（77.12±17.94）%均有明显升高；肺部重量（1302.48±380.25）g、平均肺密度（0.4302±0.0721）g·cm-1及肺部CT值（-852.70±32.41）HU均下降，差异有统计学意义（P＜0.05）。结论：定量CT应用于PAP支气管肺泡灌洗术，能够更有效地观察到治疗效果，是一种准确的观察手段，可提高患者生活质量、改善预后。

Abstract: Objective：To evaluate the value of quantitative CT in bronchoalveolar lavage of pulmonary alveolar proteinosis（PAP）. Methods： A total of 12 patients with pulmonary alveolar syndromes treated in our hospital from January 2015 to June 2016 were retrospectively selected. There were 9 males and 3 females with an average age of (40.6±4.3) years， including 8 cases 1 time， 3 cases 2 times， 1 case 3 times， and total 20 times lavage. The mean lung density， total lung weight， total lung volume， lung CT and lung function were compared before and after lavage. Results： It was found that compared to the previous lavage， PAP patient′s postoperative pulmonary lavage total volume (1655.23±832.13) mL， FVC (2.79±0.85) L， FEV1(3.03±0.38) L were increased， which were not statistically significant(P>0.05). After lavage， PaO2 (15.2±4.21) kpa， DLCO(55.35±20.29)%， and DLCO/VA (77.12±17.94)% increased. Lung weigh（1302.48±380.25）g， the mean lung density (0.4302±0.0721) g·cm-1 and lung CT value (-852.70±32.41) HU significantly decreased， the difference was statistically significant (P<0.05). Conclusion： Quantitative CT is applied to bronchoalveolar lavage with PAP， which can be used to observe the therapeutic effect more effectively. It can improve the patient′s quality of life and improve the prognosis.

王芬,贾九梅. 定量CT在肺泡蛋白沉着症支气管肺泡灌洗术中应用价值分析[J]. .

wangfen and JIA Jiumei. Application of Quantitative CT in Bronchoalveolar Lavage of Pulmonary Alveolar Proteinosis[J]. .

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