子宫颈鳞癌组织中MMP-9的表达与间质中TAMs浸润的临床意义

子宫颈鳞癌组织中MMP-9的表达与间质中TAMs浸润的临床意义

李雪莲,毛熙光

重庆市合川区人民医院 401520,西南医科大学附属医院妇科

收稿日期:2017-06-12 修回日期:2017-11-15 出版日期:2017-12-25
基金资助:
重庆市合川区科委科技项目(项目编号：合川-2016-14；项目名称：宫颈癌及CIN组织中CD68、MMP-9的表达及临床意义）

The Clinical Significance of the Expression of MMP-9 and the Infiltration of TAMs in Squamous Carcinoma of Cervix

lixuelia and MAO Xi

Hechuan district People’s Hospital of Chongqing City,The Affiliated Hospital of Southwest Medical University

Received:2017-06-12 Revised:2017-11-15 Online:2017-12-25

摘要/Abstract

摘要： 目的：探讨基质金属蛋白酶-9（MMP-9）表达与肿瘤相关巨噬细胞（TAMs）浸润与子宫颈鳞状细胞癌(squamous carcinoma of cervix，SCC)临床病理特征的关系。方法：选取50例SCC组织、30例宫颈上皮内肿瘤Ⅲ级组织(CINⅢ)及20例正常宫颈组织，采用免疫组化SP法检测MMP-9、CD68（标记TAMs）的表达。结果：SCC组织中MMP-9、CD68 阳性细胞数明显多于CINⅢ组织和正常宫颈组织；SCC组织中MMP-9、CD68的表达与SCC的浸润深度、淋巴结转移和临床分期均呈正相关；SCC组织中MMP-9与CD68的表达呈正相关。结论：TAMs的浸润数量和MMP-9的表达与SCC的浸润深度、淋巴结转移和临床分期有关，TAMs浸润数量与MMP-9的表达呈正相关，MMP-9可能参与TAMs募集，而TAMs又通过分泌更多的MMP-9促进SCC的浸润、转移。

Abstract: Objective： To investigate the relationship between expression of MMP-9 and the infiltration of TAMs in squamous carcinoma of cervix and clinicopathlogic characteristics of squamous carcinoma of cervix（SCC）. Methods： Fifty cases of SCC， 30 cases of cervical intraepithelial neoplasia Ⅲ(CINⅢ) and 20 cases of normal cervical tissues were enrolled. SP immunohistochemical method was used to detect the expression of MMP-9 and CD68 （marked as TAMs）. Results： The number of MMP-9 and CD68 positive cells in SCC tissues were more than those in CINⅢ and normal tissues；the expression of MMP-9 and the number of TAMs in squamous carcinoma tissues were positively correlated with depth of invasion，lymph node metastasis and clinical stage； the number of TAMs were positively correlated with MMP-9. Conclusion： Number of TAMs was positively correlated with depth of invasion， lymph node metastasis and clinical stage in SCC tissues． The number of TAMs was positively correlated with the MMP-9，indicating that MMP-9 may be involved in the TAMs to raise， meanwhile the TAMs may secrete more MMP-9 to promote SCC invasion and metastasis.

李雪莲,毛熙光. 子宫颈鳞癌组织中MMP-9的表达与间质中TAMs浸润的临床意义[J]. .

lixuelia and MAO Xi. The Clinical Significance of the Expression of MMP-9 and the Infiltration of TAMs in Squamous Carcinoma of Cervix[J]. .

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