血清C反应蛋白及补体C3水平与急性阑尾炎患儿预后相关性

血清C反应蛋白及补体C3水平与急性阑尾炎患儿预后相关性

王晶,甘轶文,贺笑笑

江苏省南京同仁医院儿科,江苏省南京同仁医院儿科,江苏省南京同仁医院儿科

收稿日期:2017-08-28 修回日期:2017-12-13 出版日期:2017-12-25

Correlation between Serum C Reactive Protein and Complement C3 Levels and Prognosis in Children with Acute Appendicitis

Jing Wong,Gan Yi-wen and He xiao-xiao

Department of Pediatrics,Tongren Hospital,Nanjing,Jiangsu Province,Department of Pediatrics,Tongren Hospital,Nanjing,Jiangsu Province,Department of Pediatrics,Tongren Hospital,Nanjing,Jiangsu Province

Received:2017-08-28 Revised:2017-12-13 Online:2017-12-25

摘要/Abstract

摘要： 目的：探讨血清中C反应蛋白（CRP）和补体C3水平在急性阑尾炎患儿预后中的关系。方法：筛选我院收治确诊为急性阑尾炎的32例患儿以及28例健康儿童血液样本，检测血清CRP和C3水平。对相关的各检测结果分别进行Pearson直线相关性分析和Logistic回归分析。结果：急性阑尾炎患儿血清CRP升高（P＜0.01），C3含量降低（P＜0.01）；随严重程度升高，CRP增加，C3降低。Pearson分析表明，CRP与C3表达呈负相关（P＜0.05）；Logistic分析表明，CRP和C3均与急性阑尾炎诊断具有显著相关性（P＜0.01）；ROC曲线分析，结果显示CRP和C3在诊断急性阑尾炎中均具有显著的价值（P<0.01）。结论：CRP与C3能够诊断儿童急性阑尾炎，评估发病严重程度，指导临床采取合理治疗措施，改善患儿预后。

Abstract: Objective： To investigate the relationship between serum C reactive protein(CRP) and complement C3 levels and prognosis in children with acute appendicitis.Methods：Blood samples of 32 cases with acute appendicitis and 28 healthy children were selected in our hospital and the levels of serum CRP and C3 were determined. Pearson linear correlation analysis and Logistic regression analysis were performed for each test result.Results： CRP level was significantly increased (P＜0.01) in children with acute appendicitis， and the content of C3 was significantly decreased (P＜0.01). With the increase of severity， CRP level was significantly increased， and complement C3 levelssignificantly decreased. Pearson analysis showed that CRP and C3 expression were negatively correlated (P<0.05). Logistic analysis showed that CRP and C3 were both significantly associated with the diagnosis of acute appendicitis(P<0.01). ROC curve analysis showed that CRP and C3 in the diagnosis of acute appendicitis had significant value (P<0.01). Conclusion： CRP and C3 can be used to diagnose acute appendicitis in children， to assess the severity of the disease， and to guide clinical treatment to improve the prognosis.

王晶,甘轶文,贺笑笑. 血清C反应蛋白及补体C3水平与急性阑尾炎患儿预后相关性[J]. .

Jing Wong,Gan Yi-wen and He xiao-xiao. Correlation between Serum C Reactive Protein and Complement C3 Levels and Prognosis in Children with Acute Appendicitis[J]. .

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