Abstract: Objective：To explore the effect of cluster-based care on the prevention of complications of ICP monitoring in patients with severe craniocerebral injury.Methods： A total of 82 patients with acute and severe brain injury admitted to the department of neurosurgery ICU of our hospital from May 2015 to February 2016 were selected as the subjects of the study.82 severe craniocerebral injury patients with ICP monitoring were randomly divided into the experimental group and the control group.The patients in the control group were treated with routine nursing of ICP， the experimental group was given ICP cluster-based care. The incidence rate of pulmonary infection， urinary infection， intracranial infection， venous catheter infection，intracranial hematoma and drainage tube obstruction of the two groups were compared， and the mechanical ventilation time，ICU time， hospitalization time， cost and satisfaction score of two groups were recorded and calculated. The data were analyzed by statistical software SPSS 17.0.Results： The incidence rate of pulmonary infection， urinary infection， intracranial infection， venous catheter infection and drainage tube obstruction in the experimental group was significantly lower than that in the control group.The differences were statistically significant(P＜0.05).There was no significant difference between the two groups in the incidence of intracranial hematoma(P＞0.05). Conclusion： Cluster-based care has significant clinical effect on the prevention of the incidence rate of complications of severe craniocerebral injury patients with ICP catheter， and it also can significantly reduce the incidence rate of infection， drainage tube obstruction and other complications. Therefore， cluster-based care can shorten the hospitalization time， reduce the economic burden of patients， and improve patients′ satisfaction.