Abstract: Objective：By adjusting the kinds and dosage of the excipients used in xiao′er feire kechuan granules， through the study of quality control， the identification method and the content determination method were tested to improve the quality standard of xiao′er feire kechuan granules. Methods：The differential interference test of Ephedra sinica Stapf， Scutellaria baicalensis Georgi and Honeysuckle in xiao′er feire kechuan granules was performed by thin layer chromatography(TLC). The interference test of Ephedra sinica Stapf， Fructus Forsythiae and Scutellaria baicalensis Georgi in xiao′er feire kechuan granules was performed by high performance liquid chromatography (HPLC)， and the contents of three batches of samples were determined. Results： The Ephedra sinica Stapf， Scutellaria baicalensis Georgi and Honeysuckle identificantion test by TLC had no interference. The Ephedra sinica Stapf， Fructus Forsythiae and Scutellaria baicalensis Georgi. Conclusion： The improved method is simple and specific.It can effectinely control the quality of xiao′er feire kechuan granules and improve the quality standards.