Abstract: Objective： To analysis 192 cases of adverse drug reactions(ADR) of cephalosporin antibiotics and study the coping strategies，and to provide reference for clinical rational drug use. Methods： 192 cases of ADR of cephalosporins in our hospital from January 1，2005 to December 31，2016 were collected.The incidence of ADR after the use of different cephalosporin antibiotics，the gender and age of the cases，the incidence of ADR by different administration route， and ADR involving organs were analyzed and the coping strategies were studied. Results： In 192 cases of ADR cephalosporins， the patients use cefuroxime sodium for injection have the highest incidence of adverse reactions， followed by cefoxitin sodium for injection and cefoperazone sodium and sulbactamsodium for injection. Among the selected patients， ADR incidence was the highest in patients over 60 years old， and women account for 59.90%， men account for 40.10%. The incidence of adverse reactions in patients given intravenous drip was higher than that in oral dosage form. The main organs involved of ADR of cephalosporins were skin and appendages， followed by digestive system，nervous system and circulatory system. Conclusion： Cephalosporin should be used according to the actual situation of the patients.The adverse reactions caused by cephalosporins should be effectively controlled.When the ADR occurs， the drug should be discontinued in time，and the effective treatment should be taken.