清肺平喘汤联合西药治疗小儿支气管哮喘对肺功能保护及免疫功能恢复的影响

清肺平喘汤联合西药治疗小儿支气管哮喘对肺功能保护及免疫功能恢复的影响

周耀铃,王俊霞,李静,王秋苓,张晶洁

北京市昌平区中西医结合医院 102208,北京市昌平区中西医结合医院 102208,北京市昌平区中西医结合医院 102208,北京市昌平区中西医结合医院 102208,北京市昌平区中西医结合医院 102208

收稿日期:2018-07-30 修回日期:2018-10-12 出版日期:2018-11-25

Effects of Qingfei Pingchuan Decoction Combined with Western Medicine on Lung Function Protection and Immune Function Recovery in Children with Bronchial Asthma

ZHOU Yaoling,WANG Junxia,LI Jing,WANG Qiuling and ZHANG Jingjie

Beijing Changping District Chinese and Western Medical Association Hospital,Beijing Changping District Chinese and Western Medical Association Hospital,Beijing Changping District Chinese and Western Medical Association Hospital,Beijing Changping District Chinese and Western Medical Association Hospital,Beijing Changping District Chinese and Western Medical Association Hospital

Received:2018-07-30 Revised:2018-10-12 Online:2018-11-25

摘要/Abstract

摘要： 目的：探讨清肺平喘汤联合西药治疗小儿支气管哮喘的效果以及对患儿肺功能保护、免疫功能恢复的影响。方法：抽选2015年10月至2017年11月于我科就诊的小儿支气管哮喘患儿115例，根据治疗方法不同分为观察组（n=60）和对照组（n=55）。对照组患儿给予常规西药治疗，观察组患儿在此基础上给予清肺平喘汤治疗。比较治疗后临床效果，记录患儿治疗前后肺功能、免疫功能变化，对比两组患儿胸闷、咳嗽、喘息、哮鸣音改善时间，记录治疗期间两组患儿发热、恶心呕吐、腹痛、头晕等不良反应发生率。结果：治疗后，观察组患儿总有效率95.00%，高于对照组患儿总有效率78.18%（P<0.05）；治疗后，两组患儿用力肺活量（FVC）、第一秒用力呼气容积（FEV1）、FEV1/FVC等肺功能指标表达水平均有提高，且观察组患儿以上指标均分别高于对照组患儿（P<0.05）。治疗后，观察组患儿胸闷、咳嗽、喘息、哮鸣音等临床症状改善时间均短于对照组患儿（P<0.05）；治疗后，两组患儿CD4+、CD8+、CD4+/CD8+等免疫功能指标表达水平均有提高，二者对比差异均有统计学意义（P<0.05）。治疗期间，两组患儿均有出现发热、恶心呕吐、腹痛、头晕等不良反应，观察组患儿不良反应总发生率8.33%，低于对照组患儿不良反应发生率25.45%（P<0.05）。结论：给予小儿支气管哮喘患儿清肺平喘汤联合西药治疗，可改善患儿肺功能，恢复机体免疫功能，改善患儿临床症状，提高临床疗效，安全性高，效果优于单纯西药治疗，利于患儿病情恢复。

Abstract: Objective：To investigate the effect of qingfei pingchuan decoction combined with western medicine on bronchial asthma in children， and the influence on lung function protection and immune function recovery in children. Methods：115 children with bronchial asthma in our department from October 2015 to November 2017 were selected and divided into the observation group (n=60) and the control group (n=55) according to the different treatment methods. The control group was given conventional western medicine treatment， and the observation group was given qingfei pingchuan decoction on the basis of this treatment. Compare the clinical effect after treatment， record the changes of lung function and immune function of the children before and after treatment， compare the improvement time of chest distress， cough， asthma and wheeze in the two groups， and record the incidence of adverse reactions， such as fever， nausea and vomiting， abdominal pain and dizziness in the two groups of children during the treatment. Results： After treatment， the total effective rate of the children in the observation group was 95.00%， higher than that of the control group （the total effective rate was 78.18%） (P<0.05). After the treatment， the level of FVC， FEV1， FEV1/FVC and other lung function indexes in the two groups were improved， and the above indexes of the children in the observation group were higher than those of the control group (P<0.05). After treatment， the improvement time of clinical symptoms such as chest tightness， cough， asthma and wheezing in the observation group was shorter than that of the control group (P<0.05). After treatment， the levels of CD4+， CD8+， CD4+/CD8+ and other immune function indexes in the two groups were improved， and the difference was statistically significant (P<0.05). During the treatment， two groups of children had fever， nausea and vomiting， abdominal pain， dizziness and other adverse reactions. The total incidence of adverse reactions in the observation group was 8.33%， lower than that of the control group（25.45%） (P<0.05). Conclusion： The treatment effect of qingfei pingchuan decoction combined with western medicine in children with bronchial asthma can improve the lung function of children， restore the immune function of the body， improve the clinical symptoms of the children， improve the clinical curative effect and have high safety. The effect is better than simple western medicine， which is beneficial to the recovery of the patient′s condition.

周耀铃,王俊霞,李静,王秋苓,张晶洁. 清肺平喘汤联合西药治疗小儿支气管哮喘对肺功能保护及免疫功能恢复的影响[J]. .

ZHOU Yaoling,WANG Junxia,LI Jing,WANG Qiuling and ZHANG Jingjie. Effects of Qingfei Pingchuan Decoction Combined with Western Medicine on Lung Function Protection and Immune Function Recovery in Children with Bronchial Asthma[J]. .

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