Abstract: Objective：To verify the expression of miRNAs of hepatocellular carcinoma（HCC） and adjacent tissue samples，to investigate the correlation between miRNAs expression and recurrence and metastasis of liver cancer-associated with HBV in 2 years. Methods： To detect the expression of miR-21， miR-151， miR-96 and miR-198 in 30 cases of hepatocellular carcinoma and paracancerous tissue samples by real-time quantitative reverse transcriptase polymerase chain reaction，and analyze the relationship between the expression level of miRNAs and clinical pathological features. Results： Compared with the adjacent tissues， the expression of miR-21，miR-96 and miR-151 in hepatocellular carcinoma tissues was higher than adjacent tissues， accounting for 76.7%， 70%， 66.7% of the overall sample； and the expression of miR-198 in hepatocellular carcinoma tissues was lower than adjacent tissues， accounting for 66.7% of the overall sample. Through the analysis of clinical data， we found that the expression of miRNAs in HCC tissues was closely related to the number of tumor， differentiation， TNM stage， portal vein tumor thrombus and 2 year recurrence and metastasis（P＜0.05）.Conclusion： There are obvious differences in the expression level of miRNAs in HCC tissue samples， and was associated with the malignant phenotype of hepatocellular carcinoma；miR-21，miR-151 and miR-96 can promote the invasion and metastasis of HCC， and miR-198 can inhibit the invasion and metastasis of HCC， interaction of miRNAs can affect the prognosis of patients.