关键词: 肾图, 甲氨蝶呤化疗, 白血病患儿, 中/高危急性淋巴细胞白血病, 治疗

Abstract: Objective：To explore the application of renogram in high-dose methotrexate（HD-MTX） chemotherapy for the treatment of children with middle / high risk acute lymphoblastic leukemia(ALL). Methods：A total of 68 cases of middle / high risk ALL children treated in our hospital were selected from May 2016 to May 2017， and randomly divided into the study group (medical record number was even) and the control group (medical record number was odd)， with 34 cases in each group. The study group was given renogram examination before chemotherapy， while the control group was treated with only conventional treatment without renogram examination before chemotherapy. Their treatment efficacy and satisfactory degree of family members were timely recorded and compared between the two groups. Results：The treatment efficacy and family members′ satisfaction in the study group were better than those of the control group (P<0.05). Conclusion：Renogram examination applied before chemotherapy for children with middle/high risk ALL can help doctors to appropriately manage the dose of methotrexate， and reduce adverse reactions caused by high-dose methotrexate， improve the satisfaction degree of family members.

Key words: Renogram, Methotrexate chemotherapy, Leukemia children, Middle/high risk acute lymphoblastic leukemia, Treatment