关键词: 线粒体途径, 细胞凋亡, 线粒体蛋白, 信号通路, 中枢神经系统疾病

Abstract: With the increasingly prominent problem of aging population， the incidence of central nervous system diseases such as Alzheimer's disease， Parkinson's disease and ischemic cerebrovascular disease is increasing rapidly. Up to now， its pathogenesis has not been clarified， and the whole process of central nervous system injury is accompanied by a large number of nerve cell apoptosis， and mitochondria act as cell energy suppliers and metabolic centers. Mitochondria plays an important role in the process of apoptosis. Therefore， study of the mechanism of mitochondrial-mediated apoptosis in central nervous system diseases is particularly important, which will help to reveal the key targets of mitochondrial apoptosis and provide a new idea and method for the prevention and treatment of central nervous system diseases.This paper reviews the mechanism of mitochondrial apoptosis， the key proteins of mitochondrial pathway， the main regulatory pathways and their relationship with central nervous system diseases at home and abroad，in order to provide reference to further explore the mechanism of action of mitochondria-mediated apoptosis pathway in central nervous system diseases，

Key words: Mitochondrial pathway, Apoptosis, Mitochondrial protein, Signal pathway, Central nervous system disease