关键词: font-size:medium, ">嗜酸性粒细胞绝对值计数；急性缺血性卒中；rt-PA静脉溶栓；出血性转化；影响因素

Abstract: Objective： To investigate the association of absolute eosinophil count with hemorrhagic transformation (HT) of acute ischemic stroke(AIS) patients after rt-PA intravenous thrombolysis. Methods： Retrospective analysis was conducted on the medical records of 170 AIS patients who were treated at the neurology department of our hospital from June 2017 to June 2019. Univariate analysis was adopted to assess correlation between age， NIHSS score at admission， absolute eosinophil count， etc. and HT， then multi-factor Logical regression model was used to evaluate the risks for HT after rt-PA intravenous thrombolysis. Results： Among 170 AIS patients， 10.59% (18 cases) presented HT after rt-PA intravenous thrombolysis. There was statistically significant difference between the HT group and the non-HT group in age， NIHSS score at admission， eGFR， absolute eosinophil count， and patients number of diabetes mellitus， hypertension， atrial fibrillation (P<0.05). Multi-factor Logical regression analysis revealed that age， NIHSS score at admission， eGFR， absolute eosinophil count， diabetes mellitus， hypertension and atrial fibrillation were risks of HT (P<0.05). Furthermore， after adjusting confounding factors, HT occurrence risk for patients with absolute eosinophil count≥0.11×109·L-1 reduced by 57.2% compared with patients with absolute eosinophil count <0.11×109·L-1. Conclusion： High absolute eosinophil count is associated with lower HT occurrence risk after rt-PA intravenous thrombolysis， indicating the absolute eosinophil count at admission can be an independent predictive marker for HT after rt-PA intravenous thrombolysis.

Key words: font-size:medium, ">Absolute eosinophil count； Acute ischemic stroke； rt-PA intravenous thrombolysis； Hemorrhagic transformation； Influence factors