关键词: font-size:medium, ">超早期肠内营养；重度颅脑损伤；肠道功能紊乱；炎症反应

Abstract: Objective： To investigate the impact of ultra-early enteral nutrition on intestinal function recovery and inflammatory response in patients with severe craniocerebral injury. Methods： 136 patients with severe craniocerebral injury in our hospital， from December 2017 to December 2018， were divided into observation group and control group according to random number method， with 68 cases in each group. The control group was treated with parenteral nutrition， and the observation group was treated with ultra-early enteral nutrition. The efficacy was observed in two groups after treatment， and the albumin， prealbumin， transferrin， Glasgow score (GCS)， chronic health status score Ⅱ(APACHEⅡ)， sequential organ failure assessment score (SOFA)， D-lactic acid， endotoxin， diamine oxidase (DAO)， neuron-specific enolase (NSE)， interleukin (IL)-6 and intestinal fatty acid binding protein (I-FABP) levels of the two groups were also compared before and after treatment. Results： The total effective rate was 92.65% in the observation group， which was better than the control group(76.47%) (χ2=5.632， P<0.05). There was no statistical differences in the levels of albumin， prealbumin， transferrin， GCS， APACHEⅡ， SOFA， D-lactic acid， endotoxin， DAO， NSE， IL-6 and I-FABP between the two groups before treatment(P>0.05).After treatment the levels of albumin， prealbumin，transferrin and GCS in the two groups were higher than those before treatment (P<0.01)， the APACHEⅡ， SOFA， D-lactic acid， endotoxin， DAO， NSE， IL-6 and I-FABP levels were lower than those before treatment (P<0.01)， while the increase and decrease in the observation group were more obvious than those of the control group (P<0.01). Conclusion： Ultra-early enteral nutrition can improve the efficacy of severe craniocerebral injury， promote the recovery of body nutrition， repair gastrointestinal dysfunction， and inhibit the release of inflammatory mediators.

Key words: font-size:medium, ">Ultra-early enteral nutrition； Severe craniocerebral injury； Intestinal dysfunction； Inflammatory response