Abstract: Objective： To observe the anesthetic effect of laryngeal mask general anesthesia combined with ultrasound-guided lumbar plexus-sciatic nerve block on elderly patients undergoing hip surgery， and its impact on pain， inflammation and stress respose. Methods： 124 elderly patients who underwent hip surgery in our hospital from January 2016 to December 2018 were divided into the observation group and the control group according to random number method. Each group had 62 cases. The control group underwent laryngeal mask general anesthesia， and the observation group combined with ultrasound-guided lumbar plexus-sciatic nerve block on the basis of the control group. The anesthetic effects of the two groups were compared. The mean arterial pressure(MAP)， heart rate (HR)， and oxygen saturation (SpO2) were observed at the point of before anesthesia induction (T0)， surgical incision (T1)， surgery for 30 min (T2)， end of surgery (T3)， and postoperative 30 min (T4). The pain indexes， inflammation markers， and stress hormone levels were observed in the two groups. Results： The amount of fentanyl， complete recovery time， agitation score， postoperative retention time， get out of bed time， and hospitalization time in the observation group were less than or shorter than those in the control group (P<0.01). There was no statistical difference of MAP and HR at the point of T0 between the two groups (P>0.05)， and their levels at the point of T1-T3 were lower than those at T0 in the two groups (P<0.01). The reductions in the observation group was less than that in the control group (P<0.01). There was no significant difference in SpO2 between the two groups at each time point (P>0.05). There was no statistical difference between the two groups in β-endorphin， serotonin， neuropeptide Y， high-sensitivity C-reactive protein， tumor necrosis factor-α， interleukin-6， catecholamine， adrenocorticotropic hormone and cortisol before anesthesia (P>0.05). At day 1 and day 2 after operation， the levels of these indicators in the two groups were higher than those before anesthesia (P<0.01)， while the elevated level in the observation group was lower than that in the control group (P<0.01). Conclusion： Laryngeal mask general anesthesia combined with ultrasound-guided lumbar plexus-sciatic nerve block has significant anesthetic effect on elderly patients undergoing hip surgery， which can significantly relieve the release of pain mediums， reduce the body′s inflammation factor level and relieve the body′s stress response.