Abstract: Objective：To investigate the effect of prevention proteinuria caused by apatinib through clearing heat and removing dampness method. Methods: From March 2016 to January 2018, 80 patients with advanced stomach carcinoma chemotherapy failure in the department of oncology of our hospital were randomly divided into the observation group and the control group, with 40 cases in each group. The control group received oral apatinib 250 mg once a day for 12 weeks; the observation group on the basis of the treatment of the control group, took self-made traditional Chinese medicine decoction for 12 weeks. The levels of 24 h urinary protein, creatinine, urea nitrogen and serum cystatin C were observed before and after treatment. The efficacy after 12 weeks was compared between the two groups. Results: After 12 weeks of treatment, the levels of 24 h urinary protein and serum cystatin C of the observation group were lower than those of the control group, the difference was statistically significant (P<0.01), and the difference of creatinine and urea nitrogen between the two groups was not statistically significant (P>0.05). There was no statistical difference in efficacy after 12 weeks of treatment between the two groups (P>0.05). Conclusion: This study shows that the method of clearing heat and removing dampness plays an important role in preventing and alleviating proteinuria caused by apatinib, thus ensuring the clinical efficacy of apatinib.