五倍子枯矾方加减外洗联合维A酸乳膏治疗多发性掌跖疣的疗效分析

中国医药导刊 ›› 2019, Vol. 21 ›› Issue (9): 555-559.

五倍子枯矾方加减外洗联合维A酸乳膏治疗多发性掌跖疣的疗效分析

俞一丹

上海市浦东新区光明中医医院皮肤科

出版日期:2019-09-28 发布日期:2019-09-28
基金资助:
上海市浦东新区卫生和计划生育委员会科技发展专项基金资助(项目编号：PW2016A-29；课题名称：中药外洗方治疗掌跖疣的临床研究)

Curative effect analysis of gallnut withered alum Decoction plus subtraction external washing combined with retinoic acid cream in the treatment of multiple palmoplantar warts

YU Yidan

Department of Dermatology, Guangming Hospital of Traditional Chinese Medicine

Online:2019-09-28 Published:2019-09-28

摘要/Abstract

摘要： 目的：探讨自拟中药方（五倍子、枯矾、皂荚等）外洗联合维A酸乳膏治疗多发性掌跖疣的临床疗效。方法：选取2017年6月至2018年8月间于我院皮肤科门诊就诊的153例多发性掌跖疣患者作为研究对象，根据患者的入院序号随机分成3组，即中药外洗组、维A酸乳膏组、中药外洗与维A酸乳膏联合用药组（下简称联合用药组），每组51例。分别在治疗前、3个疗程结束时、随访3个月时记录分析各组的皮损评分，统计疗效结果。结果：三组在治疗结束时皮损评分[维A酸乳膏组（8.28±4.95）、中药外洗组（5.32±3.40）、联合用药组（2.96±3.183）]较治疗前均降低（P<0.05），且联合用药组皮损评分低于另外两组（P<0.05），而维A酸乳膏组皮损评分高于另外两组（P<0.05）；随访3个月时，维A酸乳膏组的皮损评分（10.86±2.95）高于另外两组[联合用药组（4.01±2.69）、中药外洗组（6.03±3.02）]（P<0.05）。三组总有效率分别是维A酸乳膏组44.00%、中药外洗组74.00%、联合用药组90.00%，三组总有效率差异均有统计学意义（P<0.05）。两两相比，维A酸乳膏组总有效率分别低于另外两组（P<0.05），中药外洗组总有效率低于联合用药组（P<0.05）。随访3个月时复发率（维A酸乳膏组42.86%、中药外洗组12.50%、联合用药组7.69 %），联合用药组低于维A酸乳膏组（P<0.05）。结论：通过中药外洗方加减可改善掌跖疣的皮损情况，提高其疗效，而与维A酸乳膏联合则效果更好。

关键词: Plantar wart, External washing of traditional Chinese medicine, Tretinoin cream, Skin lesion, Curative efficiency

Abstract: Objective： To investigate the curative efficiency of self-made prescription (gallnut， dired alum， gleditsia sinensis， etc.) combined with tretinoin cream in treating multiple plantar wart. Methods： 153 outpatients with multiple plantar wart in the department of dermatology of our hospital from June 2017 to Auguest 2018 were selected. According to the admission number， the patients were randomly divided into three groups， which were traditional Chinese medicine (TCM) group， tretinoin cream group and TCM combined with tretinoin cream group (hereinafter referred as the combining group)， each with 51 patients. The conditions on skin lesion were evaluated at pre-treatment， the end of 3 course of treatment and 3 months after treatment respectively. Results： Compared to pre-treatment， the scores of skin lesion in the three groups were significantly improved after completing 3 course of treatment， and scores in TCM group， the tretinoin cream group and the combining group were (5.32±3.40)， (8.28±4.95) and (2.96±3.183) points respectively (P<0.05). Compared with other two groups， the combining group presented the lowest scores and the tretinoin cream group showed the highest scores (P<0.05). The total effective rate of the three groups was 44.00% in the tretionin cream group, 74.00% in the TCM group, and 90.00% in the combing group. The total effective rate of the three groups had statistic difference (P<0.05). The total effective rate of the tretionin cream group was lower than the other two groups (P<0.05), and the total effective rate of the TCM group was lower than the combining group(P<0.05). The recurrence rate of the combining group(7.69 %) was lower compared to that of the tretinoin cream group (42.86%) (P<0.05). Conclusion： The self-made prescription with addition and subtraction method may effectively improve the skin lesion conditions and curative efficiency for patients with multiple plantar wart. It shows a better outcome while combining with tretinoin cream.

Key words: palmoplantar warts, Chinese herbal medicine external washing, addition and subtraction, retinoic acid cream, skin lesions, curative effect

. 五倍子枯矾方加减外洗联合维A酸乳膏治疗多发性掌跖疣的疗效分析[J]. 中国医药导刊, 2019, 21(9): 555-559.

参考文献

[1] 范瑞强，邓丙戌，杨志波.中医皮肤性病学[M].北京，科学技术文献出版社，2010：23-24.
[2]原丽琼.跖疣的中医文献探究及治疗概况研究进展[J].现代中西医结合杂志, 2015, 24(36):4102-4104.
[3]王文娟，赵梓纲.寻常疣的治疗进展[J].综述, 2013, 10(14):38-41.
[4]国家中医药管理局.中医病证诊断疗效标准[M].北京：中国医药科技出版社，2012:261.
[5]王娣.中西医结合治疗掌跖疣例[J].中外医学研究, 2011, 09(14):62-63.
[6]Sterling JC, Gibbs S, Haque Hussain SS, et al.British Association of Dermatologists'' guidelines for the management of cutaneous warts 2014[J].Br J Dermatol, 2014, 171(4):696-712.
[7]张健，茅伟安.寻常疣的治疗进展[J].综述评论, 2013, 34(6):369-373.
[8]尤姗姗, 陈力.中药足浴治疗多发性跖疣[J].吉林中医药, 2013, 33(5):478-479.
[9]程祖耀.寻常疣洗方治疗多发性掌跖疣例[J].浙江中医杂志, 2013, 48(2):114-114.
[10]谢雪冰，柳敏.中药外用治疗多发性跖疣临床疗效观察[J].中国医学文摘, 2014, 31(4):208-209.
[11]李庆贤, 种树彬，叶艳芬，等.局部热疗联合维酸、重组人干扰素治疗扁平疣的临床疗效分析[J].临床医学工程, 2015, 22(12):1552-1554.
[12] 王晓琴.局部温热对HPV感染角质形成细胞的促凋亡作用及促炎症细胞因子的影响 [D].沈阳：中国医科大学，2008.
[13]谢雪冰，柳敏.中药外用治疗多发性跖疣临床疗效观察[J].中国医学文摘皮肤科, 2014, 31(4):208-208.
[14] 侯家玉，方泰惠.中药药理学[M].北京：中国中医药出版社，2007:185.
[15]吴苗, 刘永林, 蔡云雅.氟尿嘧啶外涂与干扰素注射联合液氮冷冻治疗多发性跖疣的疗效及对患者免疫功能的影响[J].中国临床药理学与治疗学, 2017, 22(3):312-315.
[16]周虹, 李欢玉, 葛梦林.匹多莫德联合维酸乳膏外用治疗多发性跖疣例疗效观察[J].吉林医学, 2015, 36(7):1354-1355.
[17]李宏宇.自拟中药方熏洗治疗跖疣例[J].中医药临床杂志, 2001, 13(6):448-448.
[18]张怡. 中药熏蒸治疗成人慢性湿疹的临床疗效观察[J]. 中国城乡企业卫生, 2017(12):119-120.
[19]邵佳, 章莉, 高宜云, 等. 自拟中药熏蒸方联合盐酸多塞平乳膏治疗外阴神经性皮炎疗效观察[J]. 中医临床研究, 2017，9(16)：68-69.
[20]朱永军,耿承芳,邓乐英, 等.药物联合中药熏蒸和光疗早期预防带状疱疹后遗神经痛的效果观察[J].江西中医药,2017,48(7):49-50.

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