Abstract: Objective：To investigate the current situation of the use of carbapenems antibiotics in our hospital， this paper evaluates the rationality and problems of the use of carbapenems antibiotics in order to take corresponding measures to correct the irrationality and deficiencies in the medication of clinicians. Methods： A retrospective study was conducted to evaluate all discharged patients who used carbapenems antibiotics in our hospital in the fourth quarter of 2018 according to the Detailed Rules for the Evaluation of Clinical Application of Carbapenems Antibiotics. Results：Respiratory medicine， ICU and NICU were the top three departments in the use of carbapenems antibiotics. Carbapenems antibiotics were effective in 59 cases， accounting for 65.56%. Carbapenems antibiotics were mainly used in single-drug or two-drug regimen， accounting for 93.33%. There were 43 cases in accordance with the four provisions of the Detailed Rules for the Evaluation of Clinical Application of Carbapenems Antibiotics. 10 patients received sodium valproate at the same time. The microbial detection rate of carbapenems antibiotics reached 94.44%. Experts for were incited for the in-hospital specially used antibiotics consultation of 23 patients. 5 out of 13 wards which used carbapenems antibitics did not follow the requirements documents to conduct the registration management of special files. Conclusion：The use of carbapenems antibiotics in our hospital is basically reasonable. At the same time， there are a series of problems， such as insufficient use of some varieties， lack of consultation records， compatibility with sodium valproate， incomplete registration of special files， etc. Corresponding measures are needed to promote the rational use of carbapenems in order to reduce the risk of increased bacterial resistance.