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中国医药导刊 ›› 2020, Vol. 22 ›› Issue (3): 187-192.

• 基础研究 • 上一篇    下一篇

2型糖尿病的中医证型和中医证素与西医指标的相关性分析

 王嘉祺1, 冯燕飞2, 张政1, 马思琪3, 郑朋帅3, 葛永江4, 张成成5, 曲银娥1*   

  1. 华北理工大学 1. 基础医学院, 2. 临床医学院, 3. 研究生学院, 河北 唐山 063210;
     4. 北京斯普瑞特科技发展有限公司, 北京 100005; 5. 华北理工大学电气工程学院, 河北 唐山 063210
  • 收稿日期:2020-05-12 修回日期:2020-02-22 出版日期:2020-03-31 发布日期:2020-05-14
  • 基金资助:
    省级大学生创新训练项目(项目编号:X2019042;项目名称:绞股蓝皂苷对1型糖尿病大鼠肾损伤的保护作用及机制初探)

Correlation Analysis of TCM Syndrome Types and TCM Syndrome Elements of Type 2 Diabetes with Western Medicine Indexes

  1. 1.Basic Medical College1, Clinical Medical College2, Graduate College3, North China University of Science and Technology,
         Hebei Tangshan 063210, China; 4. Beijing Spirit Technology Development Co.,Ltd, Beijing 100000, China;
         5. Electrical Engineering College, North China University of Science and Technology, Hebei Tangshan 063210, China
  • Received:2020-05-12 Revised:2020-02-22 Online:2020-03-31 Published:2020-05-14
  • Supported by:
    绞股蓝皂苷对1型糖尿病大鼠肾损伤的保护作用及机制初探

摘要: 目的:以中医证素为核心,联合2型糖尿病的中医证型分布规律,通过填补缺失数据,结合相关性分析的方法来寻求中医证型和西医指标间、中医证素和西医指标间的关系。方法:建立基于BP神经网络的分类预测模型。以中医证素作为神经网络的输入,证型作为神经网络的输出,建立了16输入、单输出的BP神经网络模型。调查所得的证型缺失数据较少,采取直接剔除方法,并通过对统计数据进行训练,训练误差为0.011 57,由此可知模型能够表示出中医证素与证型之间对应的关系。由于其他数据缺失度很高,建立基于MCMC的多重填补模型,将身高、体重、糖化血红蛋白、空腹胰岛素、空腹血糖、空腹C肽的数据进行填充。建立多元回归模型,将与其有关的数据求解出来。分析中医指标和西医指标的关系。结果和结论:通过相关性分析可知,2型糖尿病西医指标与中医证素有关系,与部分中医证型也存在相关关系。

关键词: font-size:medium, ">2型糖尿病;BP神经网络;MCMC;多元回归;相关性分析

Abstract: Objective: With TCM syndrome elements as the core, combined with the distribution of TCM syndrome types of type 2 diabetes, the relationship between TCM syndrome types and western medicine indexes and the relationship between TCM syndrome elements and western medicine indexes were sought by filling in the missing data and combining correlation analysis. Methods:A classification prediction model based on BP neural network is established. Taking TCM syndrome elements as the input and syndrome types as the output of the neural network, a BP neural network model with 16 inputs and single output was established. The missing data of TCM syndrome types obtained in the survey were few, so the direct elimination method was adopted, and the training error was 0.011 57 through the training of statistical data, indicating that the model could show the corresponding relationship between TCM syndrome elements and syndrome types. Secondly, due to the high degree of missing of other data, a multi-filling model based on MCMC was established to fill the data of height, weight, HbAIC, fasting insulin, fasting blood glucose and fasting C-peptide. Then, a multiple regression model was established to solve the relevant data analysis of the relationship between the indicators of traditional Chinese medicine and western medicine. Results and Conclusion: The correlation analysis shows that there is a relationship between type 2 diabetes western medicine indicators and TCM syndrome elements, and also between type 2 diabetes western medicine indicators and part of TCM syndrome types.

Key words: font-size:medium, ">Type 2 diabetes; BP neural network; MCMC;Multiple regression; Correlation analysis

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