关键词: font-size:medium, ">font-size:medium, ">复方氨基酸注射液（18AA）；胎儿宫内生长受限；药品不良反应

Abstract: Objective： To observe the adverse effects of intravenous infusion of compound amino acid injection（18AA） in pregnant women with fetal intrauterine growth restriction (FGR)， and to provide theoretical basis for the application of compound amino acid in pregnant women. Methods： Retrospective analysis the occurrence time， involvement system and clinical manifestations of adverse drug reaction（ADR） of a total of 452 FGR pregnant women who were treated with intravenous infusion of compound amino acid 18AA from September 2014 to September 2019 in our hospital. FGR pregnant women were divided into the amino acid group and the compound medicine group. Results： The ADR occurred after 2 h， 2-6 h， 6 h-3 d and 3 d accounted for 70.69%， 17.24%， 6.90% and 5.17% respectively. ADR involved multiple system damage： respiratory system 68.97%， digestive system 62.07%， nervous system 44.83%， skin and accessories 34.48%. There was on significant difference in the damage of each organ between the animo acid group and the compoud medicine group (P＜0.05). Conclusion： ADR of compound amino acid injection（18AA） can cause multiple system damage in pregnant women， clinical application indications should be strictly mastered and preventive measures should be strengthened.

Key words: font-size:medium, ">font-size:medium, ">Compound amino acid injection（18AA）； Fetal intrauterine growth restriction； Adverse drug reactions