氯吡格雷联合阿司匹林治疗老年心肌梗死的临床疗效探讨

摘要/Abstract

摘要： 目的：探讨老年心肌梗死患者采用氯吡格雷、阿司匹林联合治疗的临床疗效。方法：选择我院2017年2月至2020年2月收治的110例老年心肌梗死患者作为研究对象，按照随机数字表法将患者分为研究组、对照组，每组各55例。所有患者均给予抗休克、吸氧、冠脉介入治疗、再灌注等常规治疗，对照组在常规治疗基础上采用阿司匹林治疗，研究组采用氯吡格雷、阿司匹林联合治疗。治疗2个月，比较两组患者治疗总有效率、心功能指标、凝血酶原活动度、血小板聚集率、左室重构情况及并发症发生率。结果：研究组治疗总有效率、心功能指标、左室重构指标改善情况均优于对照组（P＜0.05）；研究组凝血酶原活动度、血小板聚集率及并发症发生率均低于对照组（P＜0.05）。结论：老年心肌梗死患者在常规治疗基础上采用氯吡格雷、阿司匹林联合治疗可防止左室重构，有效抑制血小板聚集，改善凝血功能和心功能，降低并发症风险。

关键词: font-size:medium, ">阿司匹林；心功能；老年心肌梗死；临床疗效；氯吡格雷

Abstract: Objective： To investigate the clinical efficacy of clopidogrel combined with aspirin in elderly patients with myocardial infarction. Methods： 110 elderly patients with myocardial infarction treated in our hospital from February 2017 to February 2020 were selected as the subjects， and the patients were divided into the study group and the control group according to the number table method，55 cases in each group. All patients were given routine treatment such as antishock therapy， oxygen inhalation， coronary intervention， reperfusion and so on. The control group was treated with aspirin on the basis of routine treatment， and the study group was treated with clopidogrel combined with aspirin. The total effective rate and cardiac function indicators， prothrombin activity， platelet aggregation rate， left ventricular remodeling， and incidence of complications of the two groups were compared after 2 month treatment. Results： The total effective rate， cardiac function indicatord and left ventricular remodeling indicators in the study group were better than those in the control group (P<0.05)， and the activity of prothrombin， platelet aggregation rate and complication rate in the study group were lower than those in the control group (P<0.05). Conclusion： The combination of clopidogrel and aspirin on the basis of routine treatment in elderly patients with myocardial infarction can prevent left ventricular remodeling， effective inhibite platelet aggregation， improve coagulation function and cardiac function， and reduce the risk of complications.

Key words: font-size:medium, ">Aspirin； Cardiac function； Myocardial infarction inelderly patients； Clinical efficacy； Clopidogrel

中图分类号:

黄敏, 林益平, 谭平. 氯吡格雷联合阿司匹林治疗老年心肌梗死的临床疗效探讨[J]. 中国医药导刊, 2021, 23(1): 22-26.

HUANG Min, LIN Yiping, TAN Ping. Clinical Efficacy of Clopidogrel Combined with Aspirin Treating Myocardial Infarction in Elderly Patients[J]. CHINESE JOURNAL OF MEDICINAL GUIDE, 2021, 23(1): 22-26.

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