关键词: font-size:medium, ">姜紫丹乳膏；制备工艺；姜黄；银屑病；药效学

Abstract: Objective： To screen the preparation process of Jiangzidan cream by central composite design multi-factor investigation， and to explore its efficacy on mouse tail root skin psoriasis model. Methods： The gloss， uniformity， whitening absorption and stability of the cream were used as evaluation indicators， and the central composite design was used to optimize the prescription conditions that affect the quality of the cream. The blank control group， the positive group， and the Jiangzidan vaseline group were compared with the Jiangzidan cream group. In each group， the cream was evenly applied to about half of the tail of the mouse once a day. After continuous dosing 14 d， the difference in the formation of the granular layer of the tail scales of the mice in each group was observed after HE staining. Results： The best prescription of Jiangzidan cream is： stearic acid 1.5 g， peppermint oil 2.05 g， borneol 0.17 g. The results of HE staining showed that compared with the blank control group， Jiangzidan cream can promote the formation of the granular layer of the tail scales of the mice（P<0.01）， and the formation of the granular layer of the tail scales of the mice in Jiangzidan cream group had statistical difference with that in Jiangzidan vaseline group（P<0.05）. Conclusion： The Jiangzidan cream prepared under the established preparation process is stable， glossy， uniform and easy to absorb， and it can obviously promote the formation of the granular layer of the tail scales of the mice， which provide reference for the clinical treatment of psoriasis.
    
     

Key words: font-size:medium, ">Jiangzidan cream； Preparation process； Turmeric； Psoriasis； Pharmacodynamics