关键词: font-size:medium, ">全身麻醉； 七氟烷； 围术期指标； 免疫功能； 应激反应

Abstract: Objective： To investigate the effect of sevoflurane on immune function and stress response in patients undergoing general anesthesia surgery. Methods： A total of 80 patients undergoing general anesthesia in our hospital from January 2020 to December 2020 were selected and divided into the control group (n=40) and the observation group (n=40) according to a random number table. The control group was given general anesthesia with propofol combined with remifentanil， and the observation group was given general anesthesia with sevoflurane combined with remifentanil. Both groups were observed 3 d postoperatively. The perioperative indexes， T0-T4 immune function and the levels of stress indexes were compared between the two groups. Results： Compared with the control group， the postoperative spontaneous breathing recovery time， wake-up time， extubation time， and anal exhaust time in patients of the observation group were shorter than those of the control group（P<0.05）. Compared with T0， the CD4+， CD4+/CD8+， serum SOD， CAT， GSH-PX levels of of the two groups in T1-T3 of patients first decreased and then increased， and the observation group was higher than the control group（P<0.05）. The serum NE level of the two groups of patients increased first and then decreased， and the observation group was lower than the control group (P<0.05). Conclusion： Sevoflurane can effectively shorten the recovery time postoperative， protect the immune system function and alleviate oxidative stress response in patients undergoing general anesthesia.
  

Key words: font-size:medium, ">General anesthesia； Sevoflurane； Perioperative index； Immune function； Stress response