关键词: font-size:medium, ">急性缺血性脑卒中；早期降压治疗；标准血压管理；NIHSS评分

Abstract: Objective：To investigate the influence of early antihypertensive treatment on short-term prognosis of patients with acute ischemic stroke. Methods：A total of 92 patients with acute ischemic stroke admitted to the emergency advanced stroke center of our hospital from March 2018 to February 2021 were included， and were randomly divided into the early antihypertensive group and the standard blood pressure management group, with 46 cases in each group. The early antihypertensive group had blood pressure control immediately after admission， and the blood pressure were decreased by no more than 20% in 24 h until the blood pressure was controlled within the normal range and maintained stable. The standard blood pressure management group started antihypertensive treatment 1 week after admission. The degree of neurological deficit and clinical efficacy of the two groups of patients were dynamically monitored within 3 months after admission， including the changes of the National Institutes of Health Stroke Scale (NIHSS) score， the modified Rankin scale score， total therapeutic response rate and the incidence of adverse cardiac events at 7 d， 14 d， 1 month and 3 months after admission. Multivariate Logistic regression analysis of antihypertensive treatment on the short-term prognosis of stroke was carried out. Results：The NIHSS scores and modified Rankin scale scores of the two groups of patients at 7 d， 14 d， 1 month and 3 months after admission showed a decreasing trend， and the neurological function recovery of the patients in the early antihypertensive group was more obvious (P<0.05). The clinical efficacy of patients in the early antihypertensive group was better than that of the standard blood pressure management group (P<0.05). The incidence of adverse cardiac events of the two groups had statistical difference (P<0.05). The results of multivariate analysis of this study showed that blood pressure control(OR=0.298， 95%CI： 0.134-0.726， P<0.05) and NIHSS score on admission were the independent influencing factors of the short-term prognosis of stroke patients. Conclusion：This study showed that early antihypertensive treatment for acute ischemic stroke patients with onset within 24 h can promote the recovery of neurological function， provide guarantee for the prognosis of patients， and improve the treatment effect.

Key words: font-size:medium, ">Acute ischemic stroke； Early antihypertensive treatment； Standard blood pressure management； NIHSS score