关键词: font-size:medium, ">慢性阻塞性肺疾病急性加重期； 中医证型； 肺功能；血气指标；炎性因子

Abstract: Objective：To explore the relationship between different TCM syndromes types and lung function， blood gas indexes， and inflammatory factors in AECOPD patients . Methods：The clinical data of 125 AECOPD patients who were admitted to our hospital from December 2018 to December 2020 were retrospectively analyzed. According to the difference of TCM syndrome types， the patients were divided into the lung and kidney deficiency group (31 cases)， phlegm obstructing the lung group (24 cases)， phlegm stasis block the lung group (20 cases)， phlegm heat block the lung group (50 cases). The course of disease， pulmonary function， blood gas indexes， and changes in the levels of inflammatory factors of patients in each group were compared. Results：The four groups ranked by the course of disease (from long to short) were the lung and kidney deficiency group， the phlegm stasis block the lung group， the phlegm heat block the lung group， and the phlegm obstructing the lung group. Compared with the phlegm obstructing the lung group and the phlegm heat block the lung group， the phlegm stasis block the lung group and the lung and kidney deficiency group had lower the ratio of the forced expiratory volume in the first s to the forced vital capacity (FEV1/FVC)， the percentage of the volume of the forced expiratory volume in the firsts to the predicted value (FEV1 Pred)， and the partial pressure of oxygen (PO2) levels， and higher partial pressure of carbon dioxide (PCO2) levels (P<0.05). The serum procalcitonin (PCT)， high-sensitivity C-reactive protein (hs-CRP)， white blood cell count (WBC) levels in the phlegm heat block the lung group were higher than those of the phlegm obstructing the lung group， the phlegm stasis block the lung group， and the lung and kidney deficiency group (P<0.05). Conclusion：The disease progression of AECOPD is phlegm obstructing the lung syndrome， phlegm heat block the lung syndrome， phlegm stasis block the lung syndrome， and lung and kidney deficiency syndrome， and it has a certain correlation with objective indicators such as lung function， blood gas indicators， and inflammatory factors levels. And it can play an important clinical significance in the judgment of TCM syndrome types.

Key words: Chronic obstructive pulmonary disease acute exacerbation period； TCM syndrome type； Pulmonary function；Blood gas indexes, Inflammatory factors