关键词: font-size:medium, ">吡嗪酰胺；抗结核；高尿酸血症；因素分析；Logistic回归分析

Abstract: Objective：To study the influencing factors of hyperuricemia caused by pyrazinamide in the treatment of tuberculosis. Methods：A retrospective study was conducted by obtaining the case data of patients using pyrazinamide in the First People′s Hospital of Xianyang from January 1， 2016 to December 31， 2020 through hospital information system(HIS)，and single factor analysis and logistic regression model for multivariate analysis were used.Results:Among the 510 induded cases， 298 cases (58.43%) occurred hyperuricemia. Univariate analysis showed that there were significant differences(P＜0.05) in gender， age，weight and serum uric acid level between the hyperuricemia group and the non-hyperuricemia group.Logistic multivariate regression analysis showed that men had a higher risk of hyperuricemia than women， which was statistically significant(OR=1.827，95%CI:1.235-2.704，P＜0.05). Patients aged<60 years old were more prone to hyperuricemia than patients aged ≥60 years old， which was statistically significant（OR=0.512， 95%CI：0.346-0.758，P＜0.05）.Patients with serum uric acid level of 282~420 μmol·L-1 before treatment were more likely to develop hyperuricemia than those with serum uric acid level of<282 μmol·L-1before treatment(OR=4.126，95%CI:2.465-6.908， P<0.05).Conclusion：Gender， age and value of serum uric acid before medication were influencing factors of hyperuricemia induced by pyrazinamide.

Key words: font-size:medium, ">Pyrazinamide, Anti-tuberculosis, Hyperuricemia, Factor analysis, Logistic regression analysis