关键词: font-size:medium, ">中药；顽痹康丸；强直性脊柱炎；肾虚湿热型；临床疗效；安全性

Abstract: Objective：To observe the clinical efficacy of wanbikang pill in the treatment of ankylosing spondylitis with kidney deficiency dampness heat syndrome. Methods： 100 ankylosing spondylitis patients with kidney deficiency dampness heat syndrome hospitalized in the rheumatology department of our hospital from January 2018 to January 2020 were selected. According to the principle of randomization and control， the patients were divided into two groups， 50 cases in each group. The control group was given sulfasalazine enteric-coated tablets combined with meloxicam capsule， and the treatment group was given wanbikang pill on the basis of the treatment of the control group. The treatment course of both groups was 12 weeks. The blood sedimentation rate (ESR)， C-reactive protein (CRP)， bone mineral density of femoral neck， serum osteocalcin (BGP) and βIsomeric C-terminal peptide (β-CTX) levels of the two groups of patients were compared before and after the treatment. The clinical efficacy was evaluated according to ASAS20 efficacy evaluation criteria after 12 weeks of treatment. The occurrence of adverse reactions in the two groups of patients was recorded. Results: After treatment， the ESR， CRP and β-CTX levels of the two groups of patients were all lower than those before treatment， and bone mineral density of femoral neck and BGP levels were higher than those before treatment(P<0.05).The improvement degree of the above indexes in the treatment group was better than that in the control group (P<0.05). After 12 weeks of treatment， the effective rate in the treatment group was 77.08%， which was higher than 52.17% in the control group (P<0.05). Conclusion： Wanbikang pill can not only reduce the inflammatory indicators (ESR and CRP) of ankylosing spondylitis patients， but also improve the bone mineral density of femoral neck， increase the level of BGP and reduce the β- CTX level， so as to achieve the balance of bone metabolism， delay disease progression， reduce bone loss， and have less adverse reactions.

Key words: Traditional Chinese medicine, Wanbikang pill, Ankylosing spondylitis, Kidney deficiency dampness heat syndrome, Clinical efficacy, Safety